Autumn 2015

In the late 1700s, a nightmare was defined as a “disease when a man in his sleep supposes he has a great weight laying upon him.”

on the brain logo.This definition came from the popular reference text, An Universal Etymological English Dictionary, first published by Nathan Bailey in 1721 and reprinted through 1802. Although that definition doesn’t surface often today, nightmares are still considered to be frightening dreams that result in feelings of terror, fear, distress, or anxiety.

Despite our colloquial use of the term, for example, “my commute was a nightmare,” for an estimated 3 to 7 percent of the U.S. population, nightmares can be a real problem. Although adults can suffer from nightmares, they are more typical in children, especially those between the ages of 3 and 6. “We think that some of this may be evolutionary,” says Deirdre Barrett, PhD, an HMS assistant clinical professor of psychology at Cambridge Health Alliance and editor of “Trauma and Dreams,” published by Harvard University Press in 2001. “Children are smaller and are vulnerable to many more threats than adults. Nightmares may partially reflect this vulnerability.”

Dreams are understood to be recent autobiographical episodes that become woven with past memories to create a new memory that can be referenced later, but nightmares are simply dreams that cause a strong but unpleasant emotional response. Dreams are part of the brain’s default network—a system of interconnected regions, which includes the thalamus, medial prefrontal cortex, and posterior cingulate cortex—that remains active during comparatively quiet periods.

REM sleep is one example of a quiet period. It is a stage of sleep that is characterized by rapid eye movement, irregular heartbeat, and increased rates of respiration. REM sleep is discontinuous, chunked into four or five periods that together make up about 20 percent of our slumber. It is during these REM episodes that brain structures in the default network exert influence, and it is during REM sleep that vividly recalled dreams occur most often.

Nightmares tend to happen during the period of sleep when REM intervals lengthen; these usually occur halfway through slumber. As we prepare to awaken, memories begin to integrate and consolidate. We dream as we emerge from REM sleep. Because we tend to dream on the sleep-wake cusp, images imagined while dreaming, including the vivid, often terrifying images produced during nightmares, are remembered.

Terror-filled sleep

a man sitting on the side of his bed hunched over with his chin resting on his fist and a blanket covering him with a scared look on his face. Nightmares are often confused with night terrors, a phenomenon more likely experienced by children than adults and usually more dramatic than a nightmare. Night terrors are not technically dreams but are instead sudden fearful reactions that occur during transitions from one sleep phase to another. They typically occur two to three hours after sleep begins, when deep non-REM sleep transitions to REM sleep. Night terrors often cause children to kick, scream, and thrash about, but, because night terrors do not occur during REM sleep, most children do not remember them.

“Night terrors are a phenomenon of the deepest parts of non-REM sleep, when the brain is less active,” says Barrett. “In a night terror, a child awakens with heart pounding. There is, however, either no content to the feeling of terror or there is a simple scary image. There is not, however, the sort of narrative story you experience with dreams, including nightmares.”

John Winkelman, AM ’83, MD ’87, PhD ’83, an HMS associate professor of psychiatry who studies sleep disorders at Massachusetts General Hospital, says night terrors are often forgotten the next day because they arise during what is known as short-wave sleep, a time when neurons in the neocortex, the brain’s center for higher mental functions, are less active.