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Disease Mechanisms

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Disease Mechanisms

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Awards & Recognitions: February 2025

February 28, 2025

Honors received by HMS faculty, postdocs, staff, and students

A close-up of inflamed tissue under a microscope

Scientists Identify New Driver of Inflammation Implicated in Autoimmune Diseases

February 20, 2025

The protein can turn the body’s defenses against its own tissues to fuel inflammation and damage

Colored dots overlap within the silhouette of a rod-shaped bacterium

New Imaging Technique Illuminates Bacterial Gene Activity

February 14, 2025

Single-cell analyses expand study of virulence, antibiotic resistance

An oblong cluster of small, irregular purple shapes overlaid with brown

Research Pinpoints Weakness in Lung Cancer’s Defenses

February 7, 2025

Scientists uncover an enzyme that boosts cancer cell metabolism to fuel growth

microscope image shows blue swirls with clusters of yellow dots against a black background

Regulatory T Cells Found To Safeguard Brain Health, Memory Formation

January 28, 2025

Research identifies guardian cells dwelling in the protective layers of the brain

A gloved hand holds a Petri dish with bacteria growing in it

Drawing a Line From the Gut Microbiome to Inflammation and Depression

January 21, 2025

Study provides explanation for one bacterium’s link to mental health

Brain tissue in Huntington’s disease

New Understanding of How Genetic Mutation Causes Huntington’s Disease

January 16, 2025

Brain cell study shows mutation expands over decades, becomes rapidly toxic later in life

Cross-section of a mouse brain under a microscope shows a cluster of glioma cells tagged in green and connected neurons shown in red, concentrated around the glioma but also stretching from other areas of the brain.

Why Do Gliomas Tend To Recur in the Brain?

December 5, 2024

First look at neuron-tumor connections illuminates formation, spread

A bright circular virus particle shines in the center of an image against a dark background, with the edge of an infected cell seen in one corner.

How HIV Research Has Reshaped Modern Medicine

November 27, 2024

Decades of scientific work turned the tide on a fatal disease.

A cross-section of intestinal lining appears like irregular ovals with complex cell structures, shown in brown with green rings and occasional purple cells

Scientists Create First Blueprint of Entire Mouse Gut

November 21, 2024

Map of genes and cells by location reveals organ’s stunning resilience

A vial of blood labeled BRCA genetic test

How Even One Faulty Copy of the BRCA1 Gene Can Fuel Breast Cancer

November 11, 2024

Research adds a new twist to prevailing two-hit model, offering new insight for prevention

Illustration of a heart shaded red and blue against a dark background, with white lines and nodes overlaid on it like it is being mapped

How Cancer Immunotherapy Fuels Heart Inflammation in Some Patients

November 8, 2024

Myocarditis appears to be triggered by immune response different from the one aimed at the tumor

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