Close to one-quarter of colonoscopies performed on older adults in the U.S. may be uncalled for based on screening guidelines, a new study suggests. Mara Schonberg, HMS assistant professor of medicine at Beth Israel Deaconess Medical Center, wrote a commentary on the study.
Further coverage of a new study by David Sinclair, HMS professor of genetics, that found how resveratrol activates cellular proteins known as sirtuins that promote longer life in laboratory worms, flies and mice.
The Medicines Co’s experimental intravenous blood clot preventer Cangrelor, which is intended for use during angioplasty procedures, solidly outperformed commonly used Plavix in a pivotal late stage study, likely resurrecting the drug’s prospects. Deepak Bhatt, HMS professor of medicine at Brigham and Women’s Hospital and chief of cardiology at the VA Boston Health Care system, is a co-lead investigator of the study.
A new study by David Sinclair, HMS professor of genetics, details at a precise molecular level how resveratrol and related substances can activate an enzyme called a sirtuin. These enzymes are thought to be involved in DNA repair, inflammation, circadian clocks, and the creation of mitochondria, the power plants of the cell. Increasing the activity of sirtuins has been shown in some animal experiments to lengthen lifespan — though not in humans.
