This article is part of Harvard Medical School’s continuing coverage of medicine, biomedical research, medical education and policy related to the SARS-CoV-2 pandemic and the disease COVID-19.
As information on COVID-19 pours in from all kinds of sources, not all of them reliable, experts at Boston Children's Hospital want to bring readers the facts about how children and teens appear to be responding to the infection.
In recent weeks, several highly respected medical journals have published studies and commentaries based on observations in children and teens in China who have COVID-19. These reports have been peer-reviewed, meaning they were carefully vetted by other experts in the field. While these observations may not reflect how children are responding elsewhere, they provide an early look.
The largest study so far, published in Pediatrics, included analysis of 2,143 children with COVID-19 documented from Jan. 16 to Feb. 8 in China. It found that symptoms of the disease were generally less severe in children and teens compared with adults. Specifically, 4.4 percent had no symptoms, 50.9 percent had mild disease and 38.8 percent had moderate symptoms.
Of the children with symptoms, only 0.6 percent developed acute respiratory distress syndrome or multiple organ dysfunction. Of note, however, young children—particularly infants under one year of age—had a higher risk for significant illness. Ten percent of infants had severe disease, compared with 3 percent of teens over age 15.
A study published March 18 in the New England Journal of Medicine reported from the major medical center treating children in Wuhan, China, the original epicenter of the COVID-19 outbreak. Of 171 children and teens, about 16 percent had no symptoms. The most common symptoms were cough, sore throat and fever.
Two studies suggest that SARS-CoV-2, the virus that causes COVID-19, does not pass from an infected woman to her baby. A small study in The Lancet involving nine pregnant women who had COVID-19 pneumonia found that none of their newborns showed signs of the infection, nor was the virus detected in the mother’s milk or in the fluid surrounding the baby before birth. Another study, in Frontiers in Pediatrics, followed four different COVID-19-infected pregnant women in Wuhan, China. There was no proven transmission from mother to baby during pregnancy.
A study from China published in Gastroenterology revealed that the virus has been found in feces for several weeks after diagnoses. However, it is not known whether the disease is transmitted by contact with fecal material.
Infections in children are mild
For clarity on what these findings might mean for kids and their parents, we turned to Kristin Moffitt, assistant professor of pediatrics at Harvard Medical School and associate physician in pediatrics in the Division of Infectious Diseases at Boston Children’s.
“What seems to be consistent so far, in multiple settings in multiple countries, including the U.S., is that the majority of COVID-19 infections in individuals under the age of 19 tend to be mild,” she explained. “Infection in pediatric patients of all ages tends to be associated with significantly lower rates of hospitalization and significantly lower rates of critical and severe illness.”
Most children haven’t met criteria for testing
Since testing for the virus has been limited to this point, Moffitt believes that a majority of infections in children and teens are going undiagnosed.
“Right now, testing is being prioritized for patients who meet criteria for high risk of more severe infection,” she said. “Since the large majority of pediatric patients have relatively mild infection and symptoms, most of them will not meet criteria for testing.”
Severe symptoms linked to immature immune systems
In the large Pediatrics study, the highest rate of moderate to severe illness was seen in infants.
“That probably has something to do with variations in the immune system,” said Moffitt. “It is not unusual for children under 1 year to need some sort of hospital-level intervention with any respiratory viral illness. It is related to their relatively immature immune systems.”
No documented cases of infection during pregnancy
In the handful of cases where women with confirmed COVID-19 infection gave birth, there is no evidence that the infant was infected before or during delivery. As reported in The Lancet, the youngest documented case was in a newborn at 36 hours of life in China.
“The presumption still is that these newborns are in close contact with infected caregivers and mothers and that contact with these caregivers is the mode of transmission as opposed to vertical transmission,” from mother to unborn child, said Moffitt.
She notes, however, that the number of cases in pregnant women and newborns is small, and more data are needed to exclude the possibility of vertical transmission.
Uncertain role of transmission in feces
Nearly all samples used for virus testing have been from nasal or throat swabs. Genetic material from the virus has also been detectable in the stool of patients with confirmed infection, even as far out as several weeks after diagnosis. Could contact with that stool pose a risk of infection?
“Whether or not that is a source of transmissible virus is still not clear,” said Moffitt. “For that reason, we strongly recommend very careful hand hygiene and decontamination of surfaces where toileting or diaper changes take place.”
Adapted from a post on Discoveries, the Boston Children's research and clinical innovation portal.