Metabolic changes in the mother during pregnancy have been linked to impaired fetal development and an increased risk of obesity, diabetes and cardiovascular problems as children reach adulthood, but the physiological origins of these changes in children are unknown. A research team used a mouse model of insulin resistance to find out how it affects metabolism and endocrine pancreas development in the offspring. The research team includes Sevim Kahraman, research fellow in medicine at Joslin Diabetes Center, Ercument Dirice, research fellow in medicine at Joslin Diabetes Center, Dario DeJesus, associate in medicine at Joslin Diabetes Center, and Rohit Kulkarni, associate professor of medicine at Joslin Diabetes Center.
