It used to be that finding genes that are important for cellular processes in mammalian cells required randomly disrupting those genes by chemical mutation or by insertion of a transposon into the genome. But then, about 10 years ago, RNA interference (RNAi) came along. Research by Stephen Elledge, the Gregor Mendel Professor of Genetics and of Medicine at HMS, is cited. Caroline Shamu, HMS assistant professor of radiology and director of ICCB Longwood Facility, is also quoted.
