Alzheimer’s disease has no cure or effective long-term treatment. Many drug trials have failed to show lasting delays or reversals of symptoms in people who already have dementia. That’s why scientists are exploring what signatures Alzheimer’s disease might create in the body before symptoms ever begin. Rudy Tanzi, the Kennedy Professor of Neuroscience at HMS and Massachusetts General Hospital, and Reisa Sperling, HMS professor of neurology at Brigham and Women’s Hospital, are quoted.