A cross-disciplinary team of scientists, engineers, and clinicians announced today that they have begun a Phase I clinical trial of an implantable vaccine to treat melanoma, the most lethal form of skin cancer.
The effort is the fruit of a new model of translational research being pursued at the Wyss Institute for Biologically Inspired Engineering at Harvard University that integrates the latest cancer research with bioinspired technology development. It was led by Wyss Core Faculty member David J. Mooney, who is also the Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences (SEAS), and Wyss Institute Associate Faculty member Glenn Dranoff, who is co-leader of Dana-Farber Cancer Institute's Cancer Vaccine Center.
Most therapeutic cancer vaccines available today require doctors to first remove the patient's immune cells from the body, then reprogram them and reintroduce them back into the body. The new approach, which was first reported to eliminate tumors in mice in Science Translational Medicine in 2009, the year the Wyss Institute was launched, instead uses a small disk-like sponge about the size of a fingernail that is made from FDA-approved polymers. The sponge is implanted under the skin, and is designed to recruit and reprogram a patient's own immune cells "on site," instructing them to travel through the body, home in on cancer cells, then kill them.
The technology was initially designed to target cancerous melanoma in skin, but might have application to other cancers. In the preclinical study reported in Science Translational Medicine, 50 percent of mice treated with two doses of the vaccine— mice that would have otherwise died from melanoma within about 25 days— showed complete tumor regression.
"Our vaccine was made possible by combining a wide range of biomedical expertise that thrives in Boston and Cambridge," said Mooney, who specializes in the design of biomaterials for tissue engineering and drug delivery. "It reflects the bioinspired engineering savvy and technology development focus of engineers and scientists at the Wyss Institute and Harvard SEAS, as well as the immunological and clinical expertise of the researchers and clinicians at Dana-Farber and Harvard Medical School."
The cancer vaccine work has received support from the Wyss Institute, Dana-Farber, and the National Institutes of Health. In addition to Mooney, Dranoff, and Hodi, other collaborators include Wyss Senior Staff Scientist Edward Doherty, Wyss Staff Scientist Omar Ali, M.D., Jerry Ritz, M.D., Director of the Cell Processing Laboratory at Dana-Farber, Sara Russell, M.D. and Charles Yoon, M.D., surgeons at Dana-Farber, and other clinical research team members based at Dana-Farber.
For the complete release and video visit the Wyss Institute website.
