Exercise training is a well-known means of maintaining and restoring good health. However, the molecular mechanisms underlying the benefits of exercise are not yet completely understood.
A new paper by researchers at Harvard Medical School and Joslin Diabetes Center in Cell Metabolism sheds light on the complex physiological response to exercise found in mice.
Taking advantage of recent single-cell technologies and advancements in computational biology, a team led by co-author Laurie Goodyear, HMS professor of medicine at Joslin and senior investigator of Integrative Physiology and Metabolism at Joslin Diabetes Center, launched a collaboration with a computational biology and artificial intelligence lab at MIT led by co-author Manolis Kellis to investigate how three metabolic tissues respond to exercise and to high-fat diet-induced obesity at single-cell resolution.
These first-of-their-kind results provide a reference atlas of the single-cell changes induced by exercise and obesity in two different types of fat and muscle.