Brain Expansion

New technique enables rapid, high resolution imaging of entire fruit fly brain and mouse neuronal circuits

Neural processes (yellow) and pre- and post-synaptic proteins (teal and magenta) in a mouse brain. Gao et al/Science 2019

In the late 19th century, the Spanish anatomist Santiago Ramón y Cajal laid the foundation for modern neuroscience with a microscope, a pen and some paper. Applying a cell-staining technique to samples of brain tissue, he produced thousands of detailed illustrations that revealed for the first time the intricate complexity of neurons and neuronal networks. Based on his observations, Ramón y Cajal proposed that the neuron was the basic functional unit of the nervous system, a fact that would not be confirmed until the 1950s with the invention of the electron microscope.

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