George Q. Daley, MD, PhD
George Q. Daley, dean of Harvard Medical School and the Caroline Shields Walker Professor of Medicine at HMS, is an internationally recognized leader in stem cell science and cancer biology. He is also a longtime member of the HMS faculty whose work spans the fields of basic science and clinical medicine.
Daley has been professor of biological chemistry and molecular pharmacology at HMS since 2010 and was an investigator of the Howard Hughes Medical Institute from 2008 until he resigned in 2017 upon assuming the Deanship. He previously held, as its inaugural incumbent, the Samuel E. Lux, IV Chair in Hematology/Oncology at Boston Children’s Hospital and was the Robert A. Stranahan Professor of Pediatrics and Professor of Biological Chemistry and Molecular Pharmacology at HMS.
A former chief resident in medicine at Massachusetts General Hospital (1994-95), Daley maintained an active clinical practice in hematology/oncology at Mass General and then at Boston Children’s, until assuming his administrative role as director of the Pediatric Stem Cell Transplantation Program at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, a post he held until Jan. 2017.
He has served since 1995 as a member of the faculty of the Harvard-MIT Division of Health Sciences and Technology (HST), since 2004 as a founding member of the executive committee of the Harvard Stem Cell Institute, and since 2009 as an associate member of the Broad Institute of MIT and Harvard and as a core faculty member of the Manton Center for Orphan Disease Research at Boston Children’s.
Daley’s research focuses on the use of mouse and human disease models to identify mechanisms that underlie blood disorders and cancer. His lab aims to define fundamental principles of how stem cells contribute to tissue regeneration and repair and improve drug and transplantation therapies for patients with malignant and genetic bone marrow disease.
Beyond his research, Daley has been a principal figure in developing international guidelines for conducting stem cell research and for the clinical translation of stem cells, particularly through his work with the International Society for Stem Cell Research, for which he has served in several leadership positions, including president (2007-08). He has also testified before Congress and spoken in forums worldwide on the scientific and ethical dimensions of stem cell research and its promise in treating disease.
After earning his bachelor's degree magna cum laude from Harvard in 1982, Daley went on to earn his PhD in biology (1989) at MIT, working in David Baltimore’s laboratory at the MIT-affiliated Whitehead Institute for Biomedical Research.
He received his MD from HMS, graduating in 1991 with the rare distinction of summa cum laude. He then pursued clinical training in internal medicine at Mass General and was a clinical fellow at Brigham and Women’s and Boston Children’s hospitals. While running a laboratory as a Whitehead Fellow at the Whitehead Institute, he joined the HMS faculty as an assistant professor in 1995. He was promoted to associate professor in 2004, was named to an endowed chair at Boston Children’s in 2009 and became a full professor at HMS in 2010.
Daley's teaching efforts include serving as course director for the Molecular Medicine course at HMS and for an undergraduate course on stem cells in disease in the Harvard Faculty of Arts and Sciences. Earlier, for more than a decade, he led the Research in Health Sciences and Technology course in the HST program. He has trained dozens of graduate students and postdoctoral fellows and is a frequent participant in seminars and grand rounds at schools and hospitals in the Boston area and beyond. In 2012 he was recognized with the HMS A. Clifford Barger Excellence in Mentoring Award.
Important contributions from the Daley laboratory have included the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with Rudolf Jaenisch), the differentiation of germ cells from embryonic stem cells, the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts, and demonstration of the role of the LIN28/let-7 pathway in cancer. In past research, he demonstrated the central role of the BCR/ABL oncoprotein in human chronic myelogenous leukemia, work that provided critical target validation for development of Gleevec, a highly successful chemotherapeutic agent.
Daley was an inaugural winner of the National Institutes of Health Director’s Pioneer Award for highly innovative research (2004). His numerous honors include the American Philosophical Society’s Judson Daland Prize for achievement in patient-oriented research, the American Pediatric Society’s E. Mead Johnson Award for contributions to stem cell research, the American Society of Hematology’s E. Donnall Thomas Prize for advances in human-induced pluripotent stem cells and the International Chronic Myeloid Leukemia Foundation’s Janet Rowley Prize for outstanding lifetime contributions to the understanding and/or treatment of the disease. He is an elected member of the National Academy of Medicine and the American Society for Clinical Investigation, among other professional societies.
Full list of Daley publications:
Please see: Daley Publications on PubMed
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, Choe J, Jun DL, Shen X, Gregory RI,Daley GQ, Meissner A, Kellis M, Hochedlinger K, Kim J, Orkin SH. Cell Rep. 2015 Aug 19.
NF-κB activation impairs somatic cell reprogramming in ageing. Soria-Valles C, Osorio FG, Gutiérrez-Fernández A, De Los Angeles A, Bueno C, Menéndez P, Martín-Subero JI, Daley GQ, Freije JM, López-Otín C. Nat Cell Biol. 2015 Aug.
In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC Jr, Bennett JM, Benz EJ Jr, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ Jr, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA. Mayo Clin Proc. 2015 Aug.
Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Li P, Lahvic JL, Binder V, Pugach EK, Riley EB, Tamplin OJ, Panigrahy D, Bowman TV, Barrett FG, Heffner GC, McKinney-Freeman S, Schlaeger TM, Daley GQ, Zeldin DC, Zon LI. Nature. 2015 Jul 23.
Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency. Cacchiarelli D, Trapnell C, Ziller MJ, Soumillon M, Cesana M, Karnik R, Donaghey J, Smith ZD, Ratanasirintrawoot S, Zhang X, Ho Sui SJ, Wu Z, Akopian V, Gifford CA, Doench J, Rinn JL, Daley GQ, Meissner A, Lander ES, Mikkelsen TS. Cell. 2015 Jul 16.
Two new routes to make blood: Hematopoietic specification from pluripotent cell lines versus reprogramming of somatic cells. Singbrant S, van Galen P, Lucas D, Challen G, Rossi DJ, Daley GQ. Exp Hematol. 2015 Jul 2.
Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice. Abed S, Tubsuwan A, Chaichompoo P, Park IH, Pailleret A, Benyoucef A, Tosca L, De Dreuzy E, Paulard A, Granger-Locatelli M, Relouzat F, Prost S, Tachdjian G, Fucharoen S, Daley GQ, Payen E, Chrétien S, Leboulch P, Maouche-Chrétien L. Haematologica. 2015 Jun 18.
LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Tu HC, Schwitalla S, Qian Z, LaPier GS, Yermalovich A, Ku YC, Chen SC, Viswanathan SR, Zhu H, Nishihara R, Inamura K, Kim SA, Morikawa T, Mima K, Sukawa Y, Yang J, Meredith G, Fuchs CS, Ogino S, Daley GQ. Genes Dev. 2015 May 15.
Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. Jing L, Tamplin OJ, Chen MJ, Deng Q, Patterson S, Kim PG, Durand EM, McNeil A, Green JM, Matsuura S, Ablain J, Brandt MK, Schlaeger TM, Huttenlocher A, Daley GQ, Ravid K, Zon LI. J Exp Med. 2015 May 4.
Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence.Kim PG, Nakano H, Das PP, Chen MJ, Rowe RG, Chou SS, Ross SJ, Sakamoto KM, Zon LI, Schlaeger TM, Orkin SH, Nakano A, Daley GQ. J Exp Med. 2015 Apr 13.
Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. Diaz MF, Li N, Lee HJ, Adamo L, Evans SM, Willey HE, Arora N, Torisawa YS, Vickers DA, Morris SA, Naveiras O, Murthy SK, Ingber DE, Daley GQ, García-Cardeña G, Wenzel PL. J Exp Med. 2015 Apr 13.
Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR. Science. 2015 Apr 3.
De novo generation of HSCs from somatic and pluripotent stem cell sources. Vo LT, Daley GQ. Blood. 2015 Mar 11.
Metabolic switches linked to pluripotency and embryonic stem cell differentiation. Shyh-Chang N, Daley GQ. Cell Metab. 2015 Mar 3;21(3):349-50.
The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy. Wang LD, Rao TN, Rowe RG, Nguyen PT, Sullivan JL, Pearson DS, Doulatov S, Wu L, Lindsley RC, Zhu H, DeAngelo DJ, Daley GQ, Wagers AJ. Leukemia. 2015 Feb 6.
Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.Jang IH, Lu YF, Zhao L, Wenzel PL, Kume T, Datta SM, Arora N, Guiu J, Lagha M, Kim PG, Do EK, Kim JH, Schlaeger TM, Zon LI, Bigas A, Burns CE, Daley GQ. Blood. 2015 Jan 13.
Defining cellular identity through network biology. Cahan P, Morris SA, Collins JJ, Daley GQ. Cell Cycle. 2014 Nov 1;13(21):3313-4.
Deconstructing transcriptional heterogeneity in pluripotent stem cells. Kumar RM, Cahan P, Shalek AK, Satija R, DaleyKeyser AJ, Li H, Zhang J, Pardee K, Gennert D, Trombetta JJ, Ferrante TC, Regev A, Daley GQ, Collins JJ. Nature. 2014 Dec 4;516(7529):56-61.
A comparison of non-integrating reprogramming methods. Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald K, Godfrey M, Gupta D, McPherson J, Malwadkar P, Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS, Brookes E, Cherry AB, Demirbas D, Tsankov AM, Zon LI, Rubin LL, Feinberg AP, Meissner A, Cowan CA, Daley GQ. Nat Biotechnol. 2015 Jan;33(1):58-63.
A nontranscriptional role for Oct4 in the regulation of mitotic entry. Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW, Daley GQ. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15768-73.
The epithelial-mesenchymal transition factor SNAIL paradoxically enhances reprogramming.Unternaehrer JJ, Zhao R, Kim K, Cesana M, Powers JT, Ratanasirintrawoot S, Onder T, Shibue T, Weinberg RA, Daley GQ. Stem Cell Reports. 2014 Nov 11;3(5):691-8.
Dissecting Engineered Cell Types and Enhancing Cell Fate Conversion via CellNet. Samantha A. Morris, Patrick Cahan, Hu Li, Anna M. Zhao, Adrianna K. San Roman, Ramesh A. Shivdasani, James J. Collins, George Q. Daley. Cell 2014 August 14:158(4):889-902.
CellNet: Network Biology Applied to Stem Cell Engineering. Patrick Cahan, Hu Li, Samantha A. Morris, Edroaldo Lummertz da Rocha, George Q. Daley, James J. Collins. Cell 2014 August 14:158(4):903-15.
Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models. Liem H. Nguyen, Daisy A. Robinton, Marc T. Seligson, Linwei Wu, Lin Li, Dinesh Rakheja, Sarah A. Comerford, Saleh Ramezani, Xiankai Sun, Monisha S. Parikh, Erin H. Yang, John T. Powers, Gen Shinoda, Samar P. Shah, Robert E. Hammer, George Q. Daley, Hao Zhu. Cancer Cell 2014 August 11:26(2): 248-61
Effect of Developmental Stage of HSC and Recipient on Transplant Outcomes. Arora N, Wenzel PL, McKinney-Freeman SL, Ross SJ, Kim PG, Chou SS, Yoshimoto M, Yoder MC, Daley GQ. Dev Cell. 2014 Jun 9;29(5):621-8.
Lin28 sustains early renal progenitors and induces Wilms tumor. Urbach A, Yermalovich A, Zhang J, Spina CS, Zhu H, Perez-Atayde AR, Shukrun R, Charlton J, Sebire N, Mifsud W, Dekel B, Pritchard-Jones K, Daley GQ. Genes Dev. 2014 May 1;28(9):971-82.
Lin28 enhances tissue repair by reprogramming cellular metabolism. Shyh-Chang N, Zhu H, Yvanka de Soysa T, Shinoda G, Seligson MT, Tsanov KM, Nguyen L, Asara JM, Cantley LC, Daley GQ. Cell. 2013 Nov 7;155(4):778-92.
Development. A stem cell perspective on cellular engineering. Doulatov S, Daley GQ. Science. 2013 Nov 8;342(6159):700-2.
Proteolytic autodigestion: common tissue pathology in Shwachman-Diamond syndrome? Kelley JM, Tulpule A, Daley GQ. Cell Cycle. 2013 Nov 15;12(22):3457-8.
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Doulatov S, Vo LT, Chou SS, Kim PG, Arora N, Li H, Hadland BK, Bernstein ID, Collins JJ, Zon LI, Daley GQ. Cell Stem Cell. 2013 Oct 3;13(4):459-70.
Hematopoietic Defects and iPSC Disease Modeling: Lessons Learned. Kelley JM, Daley GQ. Immunol Lett. 2013 Sep 25.
Stem cells: Reprogramming in situ. De Los Angeles A, Daley GQ. Nature. 2013 Sep 11.
A chemical logic for reprogramming to pluripotency. De Los Angeles A, Daley GQ. Cell Res. 2013 Aug 27.
Stem cell metabolism in tissue development and aging. Shyh-Chang N, Daley GQ, Cantley LC. Development. 2013 Jun;140(12):2535-47.
Origins and implications of pluripotent stem cell variability and heterogeneity. Cahan P, Daley GQ. Nat Rev Mol Cell Biol. 2013 Jun;14(6):357-68.
Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Shinoda G, Shyh-Chang N, Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ. Stem Cells. 2013 Aug;31(8):1563-73.
Deciphering the rules of ceRNA networks. Cesana M, Daley GQ. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7112-3.
Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction. Tulpule A, Kelley JM, Lensch MW, McPherson J, Park IH, Hartung O, Nakamura T, Schlaeger TM, Shimamura A, Daley GQ. Cell Stem Cell. 2013 Jun 6;12(6):727-36.
Lin28: primal regulator of growth and metabolism in stem cells. Shyh-Chang N, Daley GQ. Cell Stem Cell. 2013 Apr 4;12(4):395-406.
Induced pluripotent stem cells with a mitochondrial DNA deletion. Cherry AB, Gagne KE, McLoughlin EM, Baccei A, Gorman B, Hartung O, Miller JD, Zhang J, Zon RL, Ince TA, Neufeld EJ, Lerou PH, Fleming MD, Daley GQ, Agarwal S. Stem Cells. 2013 Jul;31(7):1287-97.
Lin28a regulates germ cell pool size and fertility. Shinoda G, De Soysa TY, Seligson MT, Yabuuchi A, Fujiwara Y, Huang PY, Hagan JP, Gregory RI, Moss EG, Daley GQ. Stem Cells. 2013 May;31(5):1001-9.
Reprogrammed cells for disease modeling and regenerative medicine. Cherry AB, Daley GQ. Annu Rev Med. 2013;64:277-90.
A blueprint for engineering cell fate: current technologies to reprogram cell identity. Morris SA, Daley GQ. Cell Res. 2013 Jan;23(1):33-48.
Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition. Kim PG, Albacker CE, Lu YF, Jang IH, Lim Y, Heffner GC, Arora N, Bowman TV, Lin MI, Lensch MW, De Los Angeles A, Zon LI, Loewer S, Daley GQ. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E141-50.
Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC. Science. 2013 Jan 11;339(6116):222-6.