Master of Medical Sciences in Immunology

Kono, M, Maeda, K,  Stockton-Gavanescu, I,  Pan, W,  Umeda, M, Katsuyama, E, Burbano, C,  Orite,  S,  Vukelic, M, Yoshida, N,  Tsokos, G.  Pyruvate kinaseM2 is requisite for Th1 and Th17 differentiation.  JCI Insight 4, 2019.

Vukelic, M, Yoshida, N,  Umedia, M,  Orite, S,  Bhargava, R,  Kono,  M, Stockton-Gavanescu,  I,  Hisada,  R,  Tsokos,  G,  Calcium/Calmodulin-Dependent Protein Kinase I Associates with Phosphofructokinase to Promote Glycolysis and Limit IL-2 Production (abstract).  Arthritis Rheumatol. 2019; 71 (suppl 10).

Abolhassani, H, Chou, J, Bainter, W, Platt CD, Tavassoli M, Momen T, Tavakol M, Eslamian MH, Gharagozlou M, Movahedi M, Ghadami M, Hamidieh AA, Azizi G, Yazdani R, Afarideh M, Ghajar A, Havaei A, Chavoshzadeh Z, Mahdaviani SA, Cheraghi T, Behniafard N, Amin R, Aleyasin S, Faridhosseini R, Jabbari-Azad F, Nabavi M, Bemanian MH, Arshi S, Molatefi R, Sherkat R, Mansouri M, Mesdaghi M, Babaie D, Mohammadzadeh I, Ghaffari J, Shafiei A, Kalantari N, Ahanchian H, Khoshkhui M, Soheili H, Dabbaghzadeh A, Shirkani A, Nasiri Kalmarzi R, Mortazavi SH, Tafaroji J, Khalili A, Mohammadi J, Negahdari B, Joghataei MT, Al-Ramadi BK, Picard C, Parvaneh N, Rezaei N, Chatila TA, Massaad MJ, Keles S, Hammarström L, Geha RS, Aghamohammadi A40.Clinical, immunologic, and genetic spectrum of 696 patients with combined immunodeficiency. J. Allergy Clin. Immunol. 2018, 141, 1450–1458.

Platt, CD: Chou, J, Houlihan, P, Badran, YR, Kumar, L, Bainter, W, Poliani, PL, Perez, CJ, Dent, SYR, Clapham, DE, Benavides, F, Geha, RS. Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function. J. Allergy Clin. Immunol. 2017, 140, 1651–1659. e1.

Jabara, HH, Boyden, SE, Chou, J, Ramesh, N, Massaad, MJ, Benson, H, Bainter, W, Fraulino, D, Rahimov, F, Sieff, C, Liu, ZJ, Alshemmari, SH, Al-Ramadi, BK, Al-Dhekri, H, Arnaout, R, Abu-Shukair, M, Vatsayan, A, Silver, E, Ahuja, S, Davies, EG, Sola-Visner, M, Ohsumi, TK, Andrews, NC, Notarangelo, LD, Fleming, MD, Al-Herz, W, Kunkel, LM, Geha, RS. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nature Genetics. 2016, 48, 74–8.

Yee, CS, Massaad, MJ, Bainter, W, Ohsumi, TK, Föger, N, Chan, AC, Akarsu, NA, Aytekin, C, Ayvaz, DÇ, Tezcan, I, Sanal, Ö, Geha, RS, Chou, J. Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association. J. Allergy Clin. Immunol. 2016, 137, 879–88.e2.

Wallace, JG, Tipu, HN, Stafstrom, K, Alosaimi, MF, Massaad, MJ, Bainter, W, Geha, RS, Chou, J., Rethinking newborn screening for severe combined immunodeficiency: Lessons from an international partnership for patients with primary immunodeficiencies in Pakistan. Clin Immunol. 2019 202:29-32. 

Al-Herz W, Chou, J, Delmonte, OM, Massaad, MJ, Bainter, W, Castagnoli, R, Klein, C, Bryceson, YT, Geha, RS, Notarangelo, LD., Comprehensive Genetic Results for Primary Immunodeficiency Disorders in a Highly Consanguineous Population. Front Immunol. 2019.  

Cohen, SB, Bainter, W, Johnson, JL, Lin, TY, Wong, JCY, Wallace, JG, Jones,J, Qureshi, S, Mir,  F, Qamar, F, Cantley, LC, Geha, RS, Chou, J. Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant. J Allergy Clin Immunol. 2019;143:797-799. 

Cetinkaya PG, Ayvaz DC, Karaatmaca B, Gocmen R, Söylemezoğlu F, Bainter W, Chou J, Chatila TA, Tezcan I. A young girl with severe cerebral fungal infection due to card 9 deficiency. Clin Immunol. 2018 Jun;191:21-26. doi: 10.1016/j.clim.2018.01.002.

Fischinger S, Boudreau CM, Butler AL, Streeck H, Alter G2019. Sex differences in vaccine-induced humoral immunity. Semin Immunopathol 41, 239-49. 

Butler AL, Fischinger S, Alter G. 2019. The Antibodiome-Mapping the Humoral Immune Response to HIV. Curr HIV/AIDS 16; 169-179. 

Perugino C, AlSalem SB, Mattoo H, Della-Torre E, Mahajan VS, Ganesh G, Allard-Chamard H, Wallace Z, Montesi MB, Kreuzer J, Haas W, Stone JH, Pillai S. Identification of Galectin-3 as an auto-antigen in IgG4 related-disease.  Journal of Allergy and Clinical Immunology 2019. 143, 736-745.

Hou, S, Zhou, S, Qin, Z, Yang, L, Han, X, Yao, S, Ji, H. Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma. Am J Pathol. 2017, 187:954-62.

Ofengeim, D, Mazzitelli, S, Ito, Y, DeWitt, JP, Mifflin, L, Zou, C, Das, S, Adiconis, X, Chen, H, Zhu, H, Kelliher, MA, Levin, JZ, Yuan, J. RIPK1 mediates a disease-associates microglial response in Alzheimer’s disease. Proc Natl Acad Sci USA 2017, 114(41): 8788-8797.

Ofengeim, D, Mazzitelli, S, Ito, Y, DeWitt, JP, Mifflin, L, Zou, C, Das, S, Adiconis, X, Chen, H, Zhu, H, Kelliher, MA, Levin, JZ, Yuan, J. (2017). RIPK1 mediates a disease-associates microglial response in Alzheimer’s disease. Proc Natl Acad Sci USA 114(41): 8788-8797. 

Ishizuka, JJ, Manguso, RT, Cheruiyot, CK, Bi, K, Panda, A, et al. Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade. Nature. 2019 Jan;565(7737):43-48.

Miller, BC, Sen, DR, Al Abosy, R, Panda, A, et al. Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade. Nat Immunol. 2019 Mar;20(3):326-336.

He, S, Kahles, F, Rattik, S, Nairz, M, Anzai, A, McAlpine, M, Selgrade, D Fenn, A, Chan, C, Mindur, J, Valet, C, Halle, L, Iwamoto, Y, Wojtkiewicz, G, Weissleder, R, Nahrendorf, M, Rotllan, N, Fernandez-Hernando, C, Libby, P, Drucker, D, Swirski, F. Gut intraepithelial T cells calibrate dietary metabolism and accelerate cardiovascular disease. Nature. 2019 Feb; 566(7742):115-119.

Kohlgruber, AC, Gal-Oz, ST, LaMarche, NM, Shimazaki, M, Duguette, D, Nguyen, HN, Mina, AI, Paras, T, Tavakkoli A, von Andrian, U, Banks, AS, Shay, T, Brenner, MB, and Lynch L. γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nat Immunol. 2018, 19(5): 464-474.

Sallis, BF, Erkert L, Moñino-Romero S, Acar U, Wu R, Konnikova L, Lexmond WS, Hamilton MJ, Dunn WA, Szepfalusi Z, Vanderhoof JA, Snapper SB, Turner JR, Goldsmith JD, Spencer LA, Nurko S, Fiebiger E. An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. J Allergy Clin Immunol. 2018, 141(4):1354-1364.

Prabhala, R, Acharya, S, Stekla, M, Talluri, S, Szalat, R, Nanjappa, P, Lopez, M, Wen, K, Yenumula, C, Heubeck, A, Tai, Y, Mehta, A, Fulciniti, M, Lazo-Kallanian, S, Daley, J, Richardson, P, Anderson, K, Munshi, N. Perturbation in B Cell-Subsets Can Explain the Observed Suppression of Uninvolved Immunoglobulins and Their Impact on T Tell-Subsets As Well As Patients Outcome in Myeloma. Blood. 2017, 130:3049.

Perugino C, AlSalem SB, Mattoo H, Della-Torre E, Mahajan VS, Ganesh G, Allard-Chamard H, Wallace Z, Montesi MB, Kreuzer J, Haas W, Stone JH, Pillai S. Identification of Galectin-3 as an auto-antigen in IgG4 related-disease.  Journal of Allergy and Clinical Immunology 2019. 143, 736-745.

Gunda,V , Gigliotti, B, Ashry T, Ndishabandi, D, McCarthy, M, Zhou, Z, Amin, S, Lee, KE, Stork, T, Wirth, L, Freeman, GJ, Alessandrini, A, Parangi, S., Anti-PD-1/PD-L1 therapy augments lenvatinib's efficacy by favorably altering the immune microenvironment of murine anaplastic thyroid cancer. Int J Cancer. 2019 144: 2266-2278. 

Nobel, T.B, Livschitz, J, Eljalby, M, Janjigian, YY, Bains, MS, Adusumilli, PS, Jones, DR, and Molena, D,   Unique Considerations for Females Undergoing Esophagectomy. Ann. Surg. 2019.

 Radwanski, RE, Winston, G,  Younus, I, ElJalby, M, Yuan, M, Oh, Y, Gucer, SB, Hoffman, CE, Stieg, P.E., Greenfield, J.P., et al. (2019). Neurosurgery Training Camp for Sub-Internship Preparation: Lessons From the Inaugural Course. World Neurosurg 127, e707–e716. 

 Esterházy, D, Canesso, MCC, Mesin, L, Muller, PA, de Castro, TBR, Lockhart, A, ElJalby, M, Faria, AMC,  Mucida, D.  Compartmentalized gut lymph node drainage dictates adaptive immune responses. Nature 569,  2019, 126–130. 

ElJalby, M, Pannullo, SC, Schwartz, TH, Parashar, B,  Wernicke, AG.(2019b). Optimal Timing and Sequence of Immunotherapy When Combined with Stereotactic Radiosurgery in the Treatment of Brain Metastases. World Neurosurg  2019, 127, 397–404. 

Fryer, M. Uncertainty. JAMA Cardiol. 2018 Jul 11.

Abbink, P, Larocca, RA, Visitsunthorn, K, Boyd, M, De La Barrera, RA, Gromowski, GD, Kirilova, M, Peterson, R, Li, Z, Nanayakkara, O, Nityanandam, R, Mercado, NB, Borducchi, EN, Chandrashekar, A, Jetton, D, Mojta, S, Gandhi, P, LeSuer, J, Khatiwada, S, Lewis, MG, Modjarrad, K, Jarman, RG, Eckels, KH, Thomas, SJ, Michael, NL, Barouch DH. Durability and correlates of vaccine protection against Zika virus in rhesus monkeys. Sci Transl Med. 2017, Dec 13, 9(420).

Ricciardi,  A, Visitsunthorn, K, Dalton, JP, Ndao, M. A vaccine consisting of Schistosoma mansoni cathepsin B formulated in Montanide ISA 720 VG induces high level protection against murine schistosomiasis. BMC Infectious Diseases. 2016; 16:112.

Weinberg, RP, Koledova, VV, Schneider, K, Sambandan, TG, Grayson, A, Zeidman, G, Artamonova, A, Sambanthamurthi, R, Fairus, S, Sinskey, AJ, Rha, C. Palm Fruit Bioactives modulate human astrocyte activity in vitro altering the cytokine secretome reducing levels of TNFα, RANTES and IP-10. Sci Rep. 2018 Nov 6;8(1):16423. doi: 10.1038/s41598-018-34763-3.

Weinberg RP, Koledova VV, Subramaniam A, Schneider K, Artamonova A, Sambanthamurthi R, Hayes KC, Sinskey AJ, Rha C. Palm Fruit Bioactives augment expression of Tyrosine Hydroxylase in the Nile Grass Rat basal ganglia and alter the colonic microbiome. Sci Rep. 2019 Dec 9;9(1):18625. doi: 10.1038/s41598-019-54461-y. Erratum in: Sci Rep. 2020 Feb 13;10(1):2878. 

Nakashima, H, Alayo, QA, Penaloza-MacMaster, P, Freeman, GJ, Kuchroo, VK, Reardon, DA, Fernandez, S, Caligiuri, M, Chiocca, EA. Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells. Scientific Reports. 2018, 8:208.

Passaro, C, Alayo, Q, De Laura, I, McNulty, J, Grauwet, K, Ito, H, Bhaskaran, V, Mineo, M, Lawler, SE, Shah, K, Speranza, MC, Goins, W, McLaughlin, E, Fernandez, S, Reardon, DA, Freeman, GJ, Chiocca, EA, Nakashima, H.   Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2019 25:290-299. 

Ricklefs, FL, Alayo, Q, Krenzlin, H, et al. Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Science Advances. 2018;4(3): eaar2766. doi:10.1126/sciadv.aar2766.

Alroqi FJ, Charbonnier LM, Baris S, Kiykim A, Chou J, Platt CD, Algassim A, Keles S, Al Saud BK, Alkuraya FS, Jordan M, Geha RS, Chatila TA. Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation. J Allergy Clin Immunol. 2018, Mar,141(3): 1050-1059.

Aljabban, I, Aljabban, J, Khorfan, R, McDermott, S, Dennis, D, Jensen, W, Hadley, D.  Elucidating Idiopathic Pulmonary Fibrosis Pathogeneis Through Meta-Analysis of Public Data.  American Journal of Respiratory and Critical Care Medicine. May 2019.

Aljabban, I, Hendrikesen, B, Conte, J,  Soleimani, B.  Minimally Invasive Exchange of the HeartMate 2 (HM2) Left Ventricular Assist Device (LVAD) to HeartWare Ventricular Assist Device (HVAD) or HeartMate3 (HM3).  The Journal of Heart and Lung Transplantation, April 2019.

Alsufyani, F, Pillai, S, JAKing up resistance to immunotherapy, Sci Immunol. 2017 Oct 6, 2(16).

Mahajan VS, Alsufyani F, Mattoo H, Rosenberg I, Pillai S. Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development. Glycobiology. 2019, 29, 222-228. 

Alsufyani F, Mattoo H, Zhou D, Cariappa A, Van Buren D, Hock H, Avruch J, Pillai S. The Mst1Kinase is required for follicular B cell homing and B-1B cell development Front Immunol. 2018 Oct 17; 9:2393. doi: 10.3389/fimmu.2018.02393. eCollection 2018.

Mahajan VS, Demissie E, Alsufyani F, Kumari S, Yuen GJ, Viswanadham V, Huang A, Tran JQ, Moon JJ, Irvine DJ, Pillai S. DOCK2 sets the threshold for entry into the virtual memory CD8+T cell compartment by negatively regulating tonic TCR signaling 2020. J.Immunol, 204, 49-57.

Alsufyani F, Pillai S. Luring T cells into a gray area. Sci. Immunol. 2019 pii: eaax3917. doi: 10.1126/sciimmunol.aax3917.

Chaudhri, A,  Xiao, Y,  Klee, A, Wang, X, Zhu, B, Freeman, G.J.  PD-L1 binds with B7-1 in a Cis interaction on the same cell surface. Cancer Immunology Research. 2018 September; doi: 10.1158/2326-6066, CIR-17-0316. 

 Mahoney, K, Shukla, S,  Patsoukis, N,  Chaudhri, A Browne, E, Arazi, A,  Eisenhaure, T  Pendergraft III, W,  Hua, P,  Pham, H, Bu, X, Zhu, B,  Hacohen, N,  Fritsch, E,  Boussiotis, V, Wu, C, Freeman G J Secreted PD-L1 variant that covalently dimerizes and mediates immunosuppression. Cancer Immunology and Immunotherapy. 2018 December 18; 68:421–432. PMID: 30564891.

Hoyos-Bachiloglu, R, Chou, J, Sodroski, CN, Beano, A, Bainter, W, Angelova, M, Al Idrissi, E, Habazi, MK, Alghamdi, HA, Almanjomi, F, Al Shehri, M, Elsidig, N, Alaa Eldin, M, Knipe, DM, AlZahrani, M, Geha RS. A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations. J Clin Invest. 2017 Dec 1, 127(12):4415-4420.

Piñones, M, Landaeta, M, Bustos,  P, Toche, P, Morales, P, Escobar, C, Borzutzky, A  Hoyos,-Bachiloglu, R.  Hypersensitivity reactions to measles-mumps-rubella vaccine in patients with IgE-mediated cow's milk allergy. J Allergy Clin Immunol Pract. 2019 Jul 15. pii: S2213-2198(19)30614-2.

Piñones, M, Vizcaya, C, Pérez-Mateluna, G, Hoyos-Bachiloglu, R, Borzutzky, A. Severe Necrotic Reaction to 23-Valent Polysaccharide Pneumococcal Vaccine in a Patient with STAT3 Deficiency. J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1631-1632.

Cristi, F, Perez‐Mateluna, G, Vera‐Kellet, C, et al. Vitamin D modulates the allergic phenotype of dendritic cells in children with atopic dermatitis. Exp Dermatol. 2019; 28: 308– 311.

Platt, CD, Fried AJ, Hoyos-Bachiloglu, R, Usmani, GN, Schmidt, B, Whangbo, J, Chiarle, R, Chou, J, Geha, RS. Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1. Clin Immunol. 2017 Oct;183:142-144. 

Empitu, M, Kadariswantiningsih, I, Aizawa, M, Asanuma, K.   MAGI-2 and scaffold proteins in glomerulopathy. American Journal of Physiology-Renal Physiology 2018 315:5.

Hochbaum, DR, Zhao, Y, Farhi, SL, Klapoetke, N, Werley, CA, Kapoor, V, Zou, P, Kralj, JM, Maclaurin, D, Smedemark-Margulies, N, Saulnier, JL, Boulting, GL, Straub, C, Cho, YK, Melkonian, M, Wong, GK, Harrison, DJ, Murthy, VN, Sabatini, BL, Boyden, ES, Campbell, RE, Cohen, AE. All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins. Nature methods. 2014, (8):825-33.

Torres, A, Brownstein, CA, Tembulkar, SK, Graber, K, Genetti, C, Kleiman, RJ, Sweadner, KJ, Mavros, C, Liu, KX, Smedemark-Margulies, N, Maski, K, Yang, E, Agrawal, PB, Shi, J, Beggs, AH, D'Angelo, E, Lincoln, SH, Carroll, D, Dedeoglu, F, Gahl, WA, Biggs, CM, Swoboda, KJ, Berry, GT, Gonzalez-Heydrich, J. (2018) De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome. Mol Genet Metab Rep. 2018;16:23-29. 

Mahajan, VS, Demissie, E, Mattoo, H, Viswanadham, V, Varki, A, Morris, R, and Pillai, S. Striking immune phenotypes in diverse gene-targeted mice are driven by a copy number variant originating from a commercially available C57BL/6 strain. Cell Reports. 2016, 15, 1901-1909.

Bohrson, CL, Barton, AR, Lodato, MA, Rodin, RE, Luquette, LJ, Viswanadham, V, Gulhan, D, Cortes, I, Sherman, MA, Kwon, M, Coulter, ME, Walsh, CA, and Park, PJ. Linked-read analysis identifies mutations in single-cell DNA sequencing data. Nature Genetics 51, 749-54(2019). 

Mahajan, VS, Demissie, E, Alsufyani F, Kumari, S, Yuen, GJ, Viswanadham, V, Huang, A, Tran, JQ, Moon, JJ, Irvine, DJ, Pillai, S. DOCK2 sets the threshold for entry into the virtual memory CD8+T cell compartment by negatively regulating tonic TCR signaling 2020. J.Immunol, 204, 49-57.

Washington, C, et al. Health Disparities and Inequities in the Utilization of Diagnostic Imaging for Prostate Cancer Abdominal Radiology.   AIMA Abdominal Radiology. August 6, 2020.

Weinberg, R, Li, C, Yeh, FL, Cheung, AY, Duan, Q, Kita, D, Liu, MC, Maman, J, Luu, EJ, Wu, B, Gates, L, Jalal, M, Kwong, A, Carpenter, H, Wu, HM. 2015. “Glycosylphosphatidylinositol-Anchored Proteins as Chaperones and Co-Receptors for FERONIA Receptor Kinase Signaling in Arabidopsis.” eLife. 2015, Jun 8,4.