Simons Foundation

Several scientists in the Blavatnik Institute at Harvard Medical School are using recent grants from the Simons Foundation to propel forward the frontiers of autism and neuroscience research.

Steven A. McCarroll, PhD, the Dorothy and Milton Flier Professor of Biomedical Science and Genetics, is seeking to identify aging-associated changes in gene expression in the human brain as part of a larger collaboration spanning eight research groups and focused on two well-defined aims: to pinpoint, across a diverse array of organisms, changes in gene expression within individual cells that occur during aging, and to identify targets for interventions aimed at affecting brain function, from the cellular level to cognition.

Sandeep Robert “Bob” Datta, MD ’04, PhD ’04, a professor of neurobiology, and Bernardo Sabatini, BS ’91, MD ’99, PhD ’99, the Alice and Rodman W. Moorhead III Professor of Neurobiology, are working in collaboration with two other labs toward discovering how the neural circuits that support learning, attention, and decision-making evolve with age and how these changes contribute to age-related shifts in behavior. They hypothesize that many age-related differences in behavior and learning capacity arise not from neurodegeneration but from active remodeling of neural circuits. To test this hypothesis, they are tracking age-related changes in mice from gene expression to complex behavior.

The projects described above are part of the Simons Collaboration on Plasticity and the Aging Brain (SCPAB). This program aims to understand the changes in the brain that unfold throughout normal aging and contribute to poorer memory and other age-related cognitive decline. SCPAB and other Simons Foundation collaborations bring together groups of scientists to address topics of fundamental scientific importance in which a significant new development has created a novel area for exploration in an established field.

Another such program is the Simons Collaboration on the Global Brain (SCGB), which aims to better understand the role of internal brain processes in the arc from sensation to action, thereby discovering the nature, role, and mechanisms of the neural activity that produces cognition. Working with two other labs, Datta and Sabatini are continuing an SCGB project in which they will use new technology to automatically track a mouse’s movements and body position as it forages around its cage and performs tasks. At the same time, they will monitor the activity of a brain region called the striatum, which is involved in rewards, movements, and cognition.

Marito Hayashi, PhD, is using a SFARI Bridge to Independence Award to pursue his postdoctoral research on gut-brain communication and sensory processing in autism. (SFARI stands for Simons Foundation Autism Research Initiative.) The Bridge to Independence Award enables early-career scientists from diverse backgrounds to pursue autism research and facilitates their transition into independent faculty positions at research institutions.

“When completed, our research will chart the molecular and neuronal underpinnings of gut-brain communication in neurotypical individuals and in those with autism, making progress toward developing diagnostic and therapeutic strategies targeting the gut-brain axis,” says Hayashi, a postdoctoral fellow in the lab of cell biology professor Stephen Liberles, AB ’94, AM ’96, PhD ’00.