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Genetics

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Genetics

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Exploring CRISPR Technology To Enhance Cancer Immunotherapy

September 25, 2025

Tool identifies gene edits that boost CAR T-cell therapy effectiveness in mice

Kricket and Jonathan Seidman and industry colleague Robert McDowell share the story of the journey that led to mavacamten

The First Precision Medicine for a Genetic Heart Disease

September 11, 2025

Discoveries in the Seidman Lab gave way to a novel treatment for hypertrophic cardiomyopathy

The First Precision Medicine for a Genetic Heart Disease

September 11, 2025
Discoveries in the Seidman Lab gave way to a novel treatment for hypertrophic cardiomyopathy
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New AI Tool Pinpoints Genes, Drug Combos To Restore Health in Diseased Cells

September 9, 2025

New model could optimize drug discovery

A wide angle photo of the newly named Veritas Science Center (VSC) building.

New Research Building Renamed as Veritas Science Center

September 3, 2025

Underscores Harvard Medical School’s commitment to research and discovery

One pair of boxes shows fewer green amyloid clusters on the left and more on the right. Another pair of boxes shows a dim arc of purple and red tau on the left and a brighter arc on the right.

Could Lithium Explain — and Treat — Alzheimer’s Disease?

August 6, 2025

Study: Lithium loss ignites Alzheimer’s, but lithium compound can reverse disease in mice

Top row: Untreated stem cells contain a protein (orange) marking its ability to mature into many different kinds of cells. Bottom row: Stem cells given a cocktail of transcription factors to coax them to become microglia-like cells express an array of proteins characteristic of human microglia. Images: Wyss Institute

Improving Creation of Microglia in a Dish for Brain Research

June 10, 2025

More efficient and authentic cell creation enables immune studies, drug development

A row of four slightly overlapping COVID-19 viruses, transitioning from red on the left to blue on the right

Building Vaccines for Future Versions of a Virus

May 8, 2025

AI model EVE-Vax provides valuable clues about how a virus may evolve

Four cells under a microscope have sweeping lines and round nuclei. Hundreds of tiny yellow dots indicate abnormal RNA molecules.

What Happens When a Gene Quality-Control Mechanism Fails?

May 5, 2025

Study solves riddle of how mutations in Integrator complex relate to neurodegeneration, cancer

A watercolor painting of spiky blue circles, an evocative artist’s interpretation of viruses.

How A Small Number of Mutations Can Fuel Outbreaks of Western Equine Encephalitis Virus

April 4, 2025

Study shows how spike protein changes determine the risk of viral outbreaks

A man in a lab coat and blue latex gloves holds up a microscope slide

Probing the Mysteries of the Aging Brain

March 20, 2025

Research led by new faculty member Michael Segel focuses on mammalian lifespans

In an operating room, three people in blue surgical gowns, masks, and head covers look through microscopes while performing surgery on a patient.

Stem Cell Therapy Repairs Cornea Damage Thought Irreversible

March 10, 2025

Regenerative medicine trial shows promise using patients’ own healthy corneas

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