Feb 06, 2019 101 (3) 351-352
Vol. 101, Issue 3, Medline Page 351-352
Effects of Species-Specific Genetics on Alzheimer's Mouse Models.
In this issue of Neuron, Neuner et al. (2019) report the generation of Alzheimer's disease (AD) transgenic mouse models on a panel of 28 background strains, showing marked background-dependent phenotypic variability. These findings imply that analogous variation in human AD phenotypes may be due, at least in part, to subtle effects of genetic background.