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Paper Chase

In Vivo Imaging of CNS Injury and Disease.

J. Neurosci.. Nov 08, 2017;37(45):10808-10816.
Akassoglou K, Merlini M, Rafalski VA, Real R, Liang L, Jin Y, Dougherty SE, De Paola V, Linden DJ, Misgeld T, Zheng B.

Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California 92093


In vivo optical imaging has emerged as a powerful tool with which to study cellular responses to injury and disease in the mammalian CNS. Important new insights have emerged regarding axonal degeneration and regeneration, glial responses and neuroinflammation, changes in the neurovascular unit, and, more recently, neural transplantations. Accompanying a 2017 SfN Mini-Symposium, here, we discuss selected recent advances in understanding the neuronal, glial, and other cellular responses to CNS injury and disease within vivoimaging of the rodent brain or spinal cord. We anticipate thatin vivooptical imaging will continue to be at the forefront of breakthrough discoveries of fundamental mechanisms and therapies for CNS injury and disease.