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Two mechanisms for the extinction of gene expression in hybrid cells.
Science.Sep 2, 1988;241(4870):1205-7.
Tripputi P, Guérin SL, Moore DD.
Department of Molecular Biology, Massachusetts General Hospital, Boston.
When two different mammalian cell types are fused to generate a stable hybrid cell line, genes that are active in only one of the parents are frequently shut off, a phenomenon called extinction. In this study two distinct, complementary mechanisms for such extinction of growth hormone gene expression were identified. In hybrids formed by fusing fibroblasts to pituitary cells, pituitary-specific proteins that bind to the growth hormone promoter were absent. In addition, a negative regulatory element located near the rat growth hormone promoter was specifically activated.