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Home/Research/Paper Chase/Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4.
Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4.
Cell.Jul 01, 1988;54(1):65-72.
Peterson A, Seed B.
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
Saturation mutagenesis and a complement fixation selection have yielded CD4 point mutants with impaired antibody and human immunodeficiency virus binding. The patterns of amino acid substitution, in conjunction with previous antibody cross-blocking data, affirm the similar tertiary structures of the CD4 amino-terminal domain and immunoglobulin variable regions. Single residue substitutions affecting virus binding and syncytium formation are observed over an eight residue segment located in a portion of the molecule homologous to the second hypervariable region of an antibody combining site.