Doctors trying to use psychology to boost the power of migraine medication have made a startling discovery about how attitude can affect pain. They found that people felt relief from placebos — sugar pills — even when they knew they were taking placebos. Rami Burstein, the John Hedley-Whyte Professor of Anaesthesia, and Ted Kaptchuk, professor of medicine, both of Beth Israel Deaconess Medical Center, led the study.