Actress Angelina Jolie made a wrenching choice after a blood test detected a genetic defect that made breast cancer all but certain in her lifetime: She opted to have her breasts surgically removed. Her decision starkly highlights the less-than-ideal options available to women confronting a similar diagnosis. Eric Winer, HMS professor of medicine at the Dana-Farber/Brigham and Women’s Cancer Center, and Sharon Bober, HMS assistant professor of psychology in the Department of Psychiatry at the Dana-Farber Cancer Institute, are quoted.

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