Artificial Intelligence Innovation

One Giant Step

Researchers are building an artificial intelligence system that can mimic human clinical decision making

You’re a first-year medical student and Step 1 of three United States Medical Licensing Examinations looms. Study drills include everything from anatomy to physiology, aging to immunology. Test prep books are pored over, the content in medical texts is boiled down to flashcards, and an electronic library of an estimated 20,000 of those cards, assembled by other med students over more than five years, is being scoured and its annotated sample exam questions analyzed.

The new year dawns and with it comes the posting of the USMLE scores. You’ve earned a 272. You breathe a sigh of relief.

At the Department of Biomedical Informatics in the Blavatnik Institute at HMS, however, more studying is in order. Not by human students, but by a “proto-med student.”

An algorithm.

“We’ve been providing the algorithm with information that is increasingly complex, much like what a first-year medical student would face,” says Andrew Beam, a research associate in the department and leader of the team that’s been developing the artificial neural network. “We started by providing it with the content from basic science textbooks, moved to scientific literature, worked to increase its high-level vocabulary, introduced more targeted material, then started providing it with actual test prep material.”

“Like a medical student,” adds Beam, “artificial intelligence needs to begin with a broad foundation of knowledge so that it has a rough understanding of what the pieces are and a loose understanding of how they all fit together. If you just jump into the test prep material, everything looks random to the algorithm; it has no understanding of relationships. It has no context in which to make connections.”

Beam estimates that his team will have the algorithm ready to test for next year’s Step 1 exam. Then the team will further develop the artificial neural network so that it mimics human clinical decision making and performs on a par with a second-year medical student. They then will test it with the Step 2 exam, which assesses clinical knowledge.

Long term, the team hopes to evolve the network to achieve the diagnostic level of a fourth-year medical student, capable of analyzing clinical scenarios and applying clinical reasoning.

Building proto students was not always Beam’s career goal. As an undergraduate computer science major, he had his sights on a career as a systems engineer in Silicon Valley. Then, in his junior year of college, he took a course in artificial intelligence.

“It blew my mind,” Beam says. “It was the coolest thing—an awesome mix of philosophy, mathematics, and computer science. We pondered really fundamental questions about humanity and intelligence, everything to make an undergrad go, ‘Whoa, dude!’ ”

Beam pursued a doctorate in informatics and now develops data-driven models that improve decision making in health care. He works to create artificial intelligence systems capable of sifting and interpreting the avalanche of data that has been spawned by research in a variety of clinical specialties over the past twenty years.

Recent research has demonstrated that big data can inform diagnostic algorithms that perform as well as—in some cases, better than—physicians. Some forecast that artificial intelligence will help alleviate clinician shortages while also improving access to diagnostic care for people living in remote or underserved geographic areas.

“The success of our proto-med student project would be a sort of milestone marker for research that applies AI to medical information,” says Beam. “I also think there are some natural translational opportunities for a system that can answer general medical questions. It could be used as either a clinical physician-support tool or maybe even a type of patient-facing tool.”

“I think this could have tremendous application in either the developing world or parts of the United States where health care services are not readily available,” he adds. “It’s not about AI versus MD, but MD enhanced by AI.”

Image: John Soares