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Program Leadership

Ajay K. Singh, MBBS, FRCP, MBA
Program Director
MMSCI Program
Senior Associate Dean for Global and Continuing Education
Harvard Medical School 

Dr. Ajay K. Singh is Senior Associate Dean for Global and Continuing Education at Harvard Medical School and Director, Master in Medical Sciences in Clinical Investigation (MMSCI) Program. He leads a vibrant group of faculty and staff in developing and overseeing postgraduate medical education at HMS, as well as the Master's program in Clinical Investigation. He has been Executive Director for the Dubai Harvard Foundation of Medical Research since 2008. 

Dr. Singh completed his undergraduate and medical training in England at University College London School of Medicine. He moved to Boston in 1987 for his clinical and research renal fellowship at Tufts-New England Medical Center, which he finished in 1992, when he joined the Tufts University faculty. In 1998 he moved to the Brigham and Women’s Hospital — one of the principal teaching hospitals of Harvard Medical School — as Clinical Director of the Renal Division and Director, Dialysis Services and Associate Professor of Medicine at HMS.

In 2008 he became Chief Academic Officer and Executive Director, Dubai Harvard Foundation for Medical Research (DHFMR). Dr. Singh’s interests are in clinical research – with a particular focus on the anemia of chronic kidney disease. He led groundbreaking studies in anemia of kidney disease, including the CHOIR study, which was published in the New England Journal of Medicine, and well as being a member of the steering committees for the TREAT and DRIVE studies. More recently, he has taken on the role of leading the ASCEND Clinical development program - a phase 3 program for the development of a novel propel hydroxyls inhibitor Daprodustat. The trial is aiming to recruit 7500 patients in over countries. 

Dr. Singh is currently Editor-in-Chief of Scientific American Medicine and also Chair of the Editorial Board for Nephrology Times. He leads the office of Postgraduate Medical Education at the Brigham and Women's Hospital and in this capacity leads several HMS CME courses. He is the author of over 150 original contributions and review articles, as well as author/editor of 11 books in internal medicine and nephrology. Dr. Singh is a Fellow of the Royal College of Physicians in London, and has an MBA from Boston University.

Finnian R. Mc Causland, MBBCh, MMSc, FRCPI, PG CertMedEd
Associate Director
MMSCI Program
Assistant Professor of Medicine

Harvard Medical School 

Dr. Finnian R. Mc Causland is nephrologist at Brigham and Women's Hospital, an Assistant Professor of Medicine and the Associate Director of the Master of Medical Sciences in Clinical Investigation (MMSCI) program at Harvard Medical School. Dr. Mc Causland received his MB, BCh, BAO degrees from University College Dublin in 2003. Following his general medical and higher specialist training in Ireland, he joined the Nephrology fellowship program at Brigham and Women's and Massachusetts General Hospitals in 2009. In 2012 he graduated from Harvard Medical School with a Masters in Medical Science Degree and joined the nephrology faculty at Brigham and Women’s Hospital. Dr. Mc Causland's major research interest relates to the cardiovascular consequences associated with haemodialysis. He is the Principal Investigator of two ongoing randomized controlled trials related to the dialysate prescription and its effect on intra-dialytic blood pressure stability. He has received funding from the Irish Nephrology Society, National Kidney Foundation, American Heart Association and the National Institute of Diabetes and Digestive and Kidney Diseases. 

Core Curriculum Course Directors

Julie Buring, ScD
Professor of Medicine
Harvard Medical School
Professor of Epidemiology
Harvard T.H. Chan School of Public Health
Senior Epidemiologist
Brigham and Women's Hospital 

Dr. Julie E. Buring is Professor of Medicine at Harvard Medical School and Brigham and Women’s Hospital; and Professor of Epidemiology at the Harvard School of Public Health. 

The primary focus of her research is the epidemiology of chronic diseases, primarily cardiovascular disease and cancer, and especially among women.  Dr. Buring has been involved in the design, conduct, analysis, and interpretation of a number of large-scale cohort studies and randomized clinical trials.  She served as Principal Investigator of the Women’s Health Study, a randomized trial evaluating low dose aspirin and vitamin E in the primary prevention of cardiovascular disease and cancer, and is Principal Investigator of its current post-treatment extended follow-up; and co-Principal Investigator of VITAL, an ongoing trial of vitamin E and fish oil in the primary prevention of cardiovascular disease and cancer. 

Dr. Buring is actively involved in teaching and training, both nationally and internationally. She is a member of the Board of Scientific Counselors of the National Cancer Institute, and also serves as the Chair of the Institutional Review Board of Harvard Medical School.

Michael Cho, MD
Assistant Professor of Medicine
Harvard Medical School

Dr. Cho is a pulmonary and critical care medicine physician with expertise in genetic epidemiology of chronic lung disease with a focus on COPD.  He has led analyses of large genome-wide association and sequencing based rare variant studies across multiple cohorts.

Brian Claggett, PhD
Instructor of Medicine
Harvard Medical School

Dr. Brian Claggett graduated with a PhD in Biostatistics from the Harvard T.H. Chan School of Public Health. His methodological research interests include topics relevant to the analysis of clinical trials, including survival analysis, multiple patient-level outcomes, meta-analysis, and the identification of patient subpopulations who may or may not respond to a novel treatment. Dr. Claggett began working with Brigham and Women's Hospital in 2012 and is now an Associate Scientist in the Division of Cardiovascular Medicine at BWH and Instructor in Medicine at Harvard Medical School. He has collaborated with leading researchers investigating a variety of diseases areas, including HIV/AIDS, diabetes, and heart failure. He serves as chief statistician for the Cardiac Imaging Core Laboratory and Clinical Trials Endpoints Center, managing large, multinational, phase-3 clinical trials and overseeing the secondary analyses conducted by research fellows within the Division of Cardiovascular Medicine. Dr. Claggett was involved in the clinical trials coursework for the Harvard T.H. Chan School's Program in Clinical Effectiveness for physician-clinicians and now teaches in research training programs at Harvard Medical School

Brian Healy, PhD
Assistant Professor of Neurology
Director of Clinical Research Methodology
Office of Global Education
Harvard Medical School 

Dr. Brian Healy is an Assistant Professor of Neurology at Harvard Medical School (HMS). He is the primary biostatistician for the Partners MS Center at Brigham and Women’s Hospital, and he is a member of the Massachusetts General Hospital (MGH) Biostatistics Center. Dr. Healy has been the instructor for many courses related to biostatistics at HMS and Harvard Chan School. He is the Director of the Harvard Catalyst Certificate in Applied Biostatistics, which is a 35-week, primarily on-line course that introduces medical researchers to most commonly used techniques in the medical literature. In addition to full courses, Dr. Healy leads several short courses related to biostatistics at MGH. He has given lectures related to biostatistics for several courses including the Introduction to Clinical Investigation (ICI) and Fundamentals of Clinical and Translational Research (FaCToR) through Harvard Catalyst and the Design and Conduct of Clinical Trials at MGH. He also teaches online and on-site courses as part of the HMS-Portugal Program and the Global Clinical Scholars Research Training Program. Dr. Healy began his teaching career as a Teach For America corps member from 2000-2002. Dr. Healy’s research focuses on modeling the disease course in patients with multiple sclerosis.

Miguel Hernán, MD, DrPH
Professor of Epidemiology
Harvard T.H. Chan School of Public Health 

Miguel Hernán, MD, conducts research on how to do research. He is especially interested in methods to evaluate the comparative effectiveness of strategies for the treatment and prevention of disease. Together with collaborators in several countries, he designs analyses of electronic health records, epidemiologic studies, and pragmatic randomized trials. Miguel teaches clinical data science at the Harvard Medical School, clinical epidemiology at the Harvard-MIT Division of Health Sciences and Technology, and causal inference methodology at the Harvard T.H. Chan School of Public Health, where he is a professor in the Departments of Epidemiology and Biostatistics and has mentored over 25 doctoral students and postdoctoral fellows. Miguel is Fellow of the American Association for the Advancement of Science, Chair of the Section on Statistics and Epidemiology of the American Statistical Association, Associate Editor of the American Journal of Epidemiology and of the Journal of the American Statistical Association, and an Editor of Epidemiology.

Sonal Jhaveri, PhD
Science Program Director
Dana Farber Cancer Institute

Dr. Jhaveri is an MIT alumna (BS, MS). She received her PhD from Harvard University, has been Principal Investigator on a number of grants from NIH, NSF and other private foundations, has co-authored 60 professional articles, and has consulted on a number of science and medical writing projects. She teaches Science Communication and Language Skills to graduate and medical students, as well as to postdocs at MIT and Dana-Farber Cancer Institute.

Susan Z. Kornetsky, MPH
Director of Clinical Research Compliance
Boston Children's Hospital 

Susan Kornetsky is the Director of Clinical Research Compliance at Children’s Hospital in Boston.  Her education includes a BA in Biology from Brandeis University, and a Masters of Public Health from Boston University.  In May of 2010 she completed a Medical Ethics Fellowship at Harvard Medical School. 

Ms. Kornetsky is a past appointed member of the Secretary’s Advisory Committee on Human Research Protections (SACHRP) and was co-chair of the SACHRP Sub-committee on Children.  She currently serves on the Subpart A subcommittee of SACHRP.  She is a past member, appointed by the Secretary of HHS, of the National Human Research Protection Advisory Committee. She is a past Board member of the Association for the Accreditation of Human Research Programs (AAHRP), and is currently a site visitor.  She was a member of the Institute of Medicine’s Committee on Clinical Research Involving Children.  

Ms. Kornetsky is a Board member of Public Responsibility in Research and Medicine. She was a member on the Council for Certification of IRB Professionals (CCIP) and served as a Council co-chair. She lectures at many national meetings in addition to conferences and educational programs, and has served as a consultant on an Office of Protection from Research Risks (OPRR) site visit team.

Pearl O'Rourke, MD
Associate Professor of Medicine
Harvard Medical School
Director, Human Research Affairs
Partners HealthCare Systems 

Pearl O'Rourke is the Director of Human Research Affairs at Partners HealthCare Systems in Boston and an Associate Professor of Pediatrics at Harvard Medical School. She is responsible for the systems that support the regulatory and ethical oversight of human research and the responsible conduct of research. She is also Chair of the Partners Healthcare System ESCRO (Embryonic Stem Cell Research Oversight) Committee. Pearl has worked as a pediatric critical care physician at the Children's Hospital, Boston and at the Children's Hospital, University of Washington, Seattle where she was the Director of the Pediatric Intensive Care Unit. She was active in clinical research in extracorporeal membrane oxygenation (ECMO), liquid ventilation, high frequency ventilation and pediatric resuscitation. In Seattle she served many years as a member of the IRB. Pearl has also been involved in international medical care, serving in China and Indonesia with Project HOPE. In 1995-1996, Pearl did a Robert Wood Johnson Health Policy fellowship working for Senator Edward Kennedy. Following this fellowship, she became the Deputy Director of the Office of Science Policy in the Office of the Director at the NIH where she worked on issues such as privacy, gene therapy (transfer) embryonic stem cells, and genetic discrimination.

Benjamin Raby, MD, CM
Associate Professor of Medicine
Harvard Medical School
Director, Pulmonary Genetics Center
Brigham and Women’s Hospital 

Benjamin Raby, MD, MPH is a  pulmonologist and genetic epidemiologist with an interest in the genetics of lung disease. He is the Director of the BWH Pulmonary Genetics Center, a first-of-its kind clinical and research center that serves patients with suspected genetic pulmonary disorders. His research focuses primarily on identifying the molecular determinants of asthma in human populations. He has developed four NIH-funded studies that use genome-wide approaches. “Genetics and Gene Expression Profiling in Asthma” aims to identify asthma-associated regulatory genetic variants. He has developed gene expression signatures for asthma-associated traits and methods to facilitate expression quantitative trait locus mapping studies. These efforts resulted in identification of regulatory variants that influence the expression of 1,585 genes, including novel asthma susceptibility variants, and have developed a pipeline to functionally characterize the identified asthma genes. The second project, “The Asthma BioRepository for Integrative Genomics Research”, is a nation-wide effort to establish a publicly accessible repository of cell lines from 1,500 asthmatic and healthy subjects, accompanied by genome-wide genotype, gene expression and methylation profiles for all 1,500 subjects to facilitate integrative, systems-based approaches for the study of asthma and other traits. The third project, “Structural Genetic Variation in Asthma”, is supporting a genome-wide association study of copy number variation (CNVs) in asthma. The fourth, "Integrative Genomics of Acute Asthma Control" focuses on leveraging clinical, genomic and environmental data to understand the molecular determinants of suboptimal asthma control. I am also a founding member of the EVE Asthma Consortium, and collaborate on a variety of asthma and COPD projects.

Aneesh Singhal, MD, MBBS
Associate Professor of Neurology
Massachusetts General Hospital 

Dr. Aneesh B. Singhal is a Board Certified Neurologist, Vascular Neurologist and, Neurosonologist. He is Vice-Chair of Neurology [Quality and Safety] at Massachusetts General Hospital and Associate Professor of Neurology at Harvard Medical School in Boston, USA.  He serves on the Board of Trustees of the Partners Continuing Care and Spaulding Rehabilitation Network, is advisor to Partners HealthCare International and Neurology Foundation India. 

Dr. Singhal’s areas of research include stroke in young adults, cerebral arteriopathies, advanced brain imaging for acute ischemic stroke, and stroke neuroprotection. He is internationally recognized for his work on characterizing the reversible cerebral vasoconstriction syndrome (RCVS) and cerebral vasculitis. He was the Principal Investigator of the NIH funded Indo-US Collaborative Stroke Project, the NIH funded Phase 2 trial of Normobaric Oxygen Therapy in Acute Stroke, and is currently Deputy Principal Investigator of the New England Regional Coordinating Center (NERCC) for the NIH StrokeNet. He has served as site PI of several Industry funded stroke clinical trials. Dr. Singhal has authored or co-authored nearly 200 articles and book chapters.

Priya Singhal
Global Head and Senior Vice-President
Safety and Benefit Risk Management
Biogen, Inc.  

Priya Singhal, MD, MPH is the Senior Vice President and the Global Head of Safety and Benefit Risk Management (SABR) at Biogen since mid-2013. Priya joined Biogen in late 2012 as VP, Clinical Trials in SABR. Priya was promoted to Global Head within eight months of her joining the company.

During her Clinical Trial tenure at Biogen she led the worldwide benefit-risk strategy for the filings and approvals of Plegridy, Alprolix, Eloctate. As Global Head, she oversees all key benefit-risk medical strategy for the entire Biogen marketed portfolio as well as the development product portfolio. In addition, Priya is also responsible for SABR Operational and Epidemiology strategy and implementation.

Prior to Biogen, Priya was at Vertex Pharmaceuticals for five years from 2008-2012. During her last year at Vertex, Priya served as VP, Medical Affairs and led strategy and educational efforts across all Vertex programs including the Vertex Hepatitis C and Cystic Fibrosis portfolios. Before that, she held roles of increasing seniority in Vertex Global Patient safety and led the benefit-risk aspects of the HCV portfolio. She presented and defended the positive Telaprevir benefit-risk at the May 2011 Advisory Committee for Telaprevir that resulted in a 19-0 positive vote followed by worldwide Incivek approval. From 2005-2008, Priya led benefit-risk for Velcade at Millennium Pharmaceuticals and two compounds in the development portfolio. 

Preceding her career in the Biotechnology Industry, Priya completed her MPH in International Health at Harvard School of Public Health and led a pilot program in the Radiology Department of Massachusetts General Hospital addressing outsourcing of chest x-ray readings to India. 

Priya was born and raised in India, was trained in Internal Medicine in Mumbai, and is fluent in five Indian languages. She is an invited speaker at Academic and Industry Forums for Benefit-Risk and Drug Development and serves as the Biogen lead for PhRMA benefit-risk initiatives and CIRS (Center for Innovation of Regulatory Sciences). Priya is a recipient of several company awards on her outstanding contributions and notably a recipient of Healthcare Business Woman Rising Star award in 2012.

Caren G. Solomon, MD, MPH
Associate Professor of Medicine
Harvard Medical School
Deputy Editor
New England Journal of Medicine
Associate Physician
Brigham and Women's Hospital 

Dr. Solomon is a Deputy Editor at the New England Journal of Medicine, where she is responsible for the “Clinical Practice” series (a triweekly series of evidence-based review articles relevant to the practicing clinician), the Clinical Problem Solving series (a monthly series of case discussions), interactive on-line cases, and original articles related to women's health and general medicine. Dr. Solomon obtained her MD from Harvard Medical School and an MPH from the Harvard School of Public Health. She is an Associate Professor of Medicine at Harvard Medical School and maintains a part-time clinical practice at the BWH Fish Center for Women’s Health. Dr Solomon continues research on a part-time basis, collaborating on epidemiologic and clinical studies of gestational diabetes and other disorders of insulin resistance in women.

Scott Solomon, MD
Edward D. Frohlich Distinguished Chair
Professor of Medicine
Harvard Medical School
Senior Physician and Director Noninvasive Cardiology
Brigham and Women's Hospital 

Scott D. Solomon, MD is The Edward D. Frohlich Distinguished Chair, Professor of Medicine at Harvard Medical School, Director of Noninvasive Cardiology and Senior Physician at Brigham and Women’s Hospital. He directs the Cardiac Imaging Core Laboratory and the Clinical Trials Endpoints Center at Brigham and Women’s Hospital. He received his A.B. from Williams College and his M.D. from Harvard Medical School. Dr. Solomon’s research interests have focused on changes in ventricular structure and function following myocardial injury, modifiers of risk and influences of outcome in patients following myocardial infarction and with chronic heart failure, cardiovascular safety of non-cardiovascular therapies, factors that influence the transition from hypertension to heart failure, and heart failure with preserved ejection fraction. He has pioneered the use of cardiac imaging in cardiovascular drug and device development and use of imaging in clinical trials. He and his research group have played a leading role in many international clinical trials in heart failure, hypertension and myocardial infarction, including the SAVE, HEART, VALIANT, CHARM, PEACE, OVERTURE, MADITCRT,ALOFT, ALLAY, TREAT, RED-HF, ALTITUDE, FREEDOM, TOPCAT trials. He led the NIH sponsored Celecoxib Cross-trials Safety Study which directly informed regulatory agencies about the safety of widely used non-steroidal anti-inflammatory agents. He directs the Cardiac Imaging Center for the NHLBI Atherosclerosis Risk in Communities (ARIC) study and Hispanic Community Health Study – Study of Latinos (HCHS-SOL), the two largest NIH cohort studies. Dr. Solomon has recently studied the role for angiotensin receptor neprilysin inhibition in heart failure. He served as member of the executive committee for the PARADIGM-HF trial, led the first successful Phase II trial in heart failure with preserved ejection fraction and is currently leading the ongoing PARAGON-HF outcomes trial in HFpEF. He is PI for the NHLBI funded INVESTED trial studying influenza vaccine to reduce cardiovascular events. Dr. Solomon leads a research group consisting of 10 faculty members, 8 research fellows and 40 support staff. He currently receives, or has received, extensive research support from the NIH and multiple industry sponsors. He has directed the Harvard Medical School Cardiovascular Clerkship and the Echocardiography training program at Brigham and Women’s Hospital. He has authored more than 400 peer-reviewed articles, reviews and editorials, two textbooks of cardiac imaging, and the Echocardiograph/Imaging sections for the 10th edition of Braunwald’s Heart Disease and 19th edition Harrison’s Principles of Internal Medicine. He is listed by Thomson-Reuters as one of the most highly cited scientists in the past 10 years. He is a Cardiology Section Editor at UpToDate and International Associate Editor at the European Heart Journal.

Sushrut Waikar, MD, MPH
Associate Professor of Medicine
Harvard Medical School
Constantine L. Hampers Distinguished Chair
& Director of Translational Research, Renal Division
Brigham and Women's Hospital

Dr. Waikar is the Constantine L. Hampers, MD Distinguished Chair in Renal Medicine at BWH and the director of translational research and renal ambulatory services. He is an active clinician as well as clinical researcher. Dr. Waikar’s research interests are inspired by the patients and clinical problems he sees in the clinics and inpatient units at BWH. He uses epidemiologic, translational, and interventional studies to address novel and clinically important questions in nephrology. His current areas of investigation include optimal diagnostic testing in acute kidney injury and chronic kidney disease; biomarkers of kidney pathology and kidney fibrosis; the identification of relevant targets for interventional trials in acute kidney injury; randomized controlled trials to improve the safety of hemodialysis and hemofiltration; and improving the delivery of care to patients with acute kidney injury and chronic kidney disease.

MMSCI Lectures

Ranjay Gulati, BA, BS, SM, PhD
Chair of Advanced Management Program
Professor of Business Administration
Harvard Business School

Sonia Hernandez-Diaz, MD
Instructor in Pediatrics
Harvard Medical School

E. Francis Cook Jr., SC.D.
Professor of Medicine
Harvard T.H. Chan School of Public Health

Soumya Ghosh, PhD
Research Scientist
IBM Research

Andrew Beam, PhD
Instructor in Biomedical Informatics
Harvard Medical School

Marc Pfeffer, MD, PHD
Victor J. Dzau Professor of Medicine
Brigham and Women’s Hospital

Tom Gaziano, MD
Assistant Professor of Medicine
Brigham and Women’s Hospital

Susan Fish
Professor of Biostatistics and Epidemiology
Boston University School

Libby Hohmann, MD
Associate Professor of Medicine
Massachusetts General Hospital

Melissa Frumin, MD
Brigham and Women’s Hospital

Sarah White
Director of Human Research Quality Improvement Program
Partners’ Healthcare

Sally Okun
Vice President for Advocacy, Policy and Patient Safety

Robert Truog, MD
Director of Center for Bioethics
Harvard Medical School
Frances Glessner Lee Professor of Legal Medicine, Professor of Anesthesia
Children’s Hospital

Luke Gelinas, PhD
Course Instructor
Harvard Medical School

Sara Lodi, PhD
Research Fellow
Harvard T.H. Chan School of Public Health

Paul Ridker, MD
Eugene Braunwalk Professor of Medicine
Brigham and Women’s Hospital 

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