Department of Pathology Research Faculty - BWH, MGH, BIDMC, BCH
Disciplines
Cancer
Jon C. Aster, M.D., Ph.D., Professor of Pathology, Brigham and Women’s Hospital, "Notch signaling in cancer” (https://connects.catalyst.harvard.edu/Profiles/display/Person/48586 )
Bradley Bernstein, MD, PhD; Professor of Pathology, MGH,“Chromatin biology and cancer epigenetics” (http://bernstein.mgh.harvard.edu/)
Ruben D. Carrasco, MD, PhD; Associate professor of Pathology, Dana-Farber Cancer Institute, “Functional characterization and targeting of oncogenic pathways in mouse models” (https://connects.catalyst.harvard.edu/Profiles/display/Person/57176 )
Li Chai, MD, Associate Professor of Pathology, Brigham and Women’s Hospital, “Transcriptional factor, Chromatin modifier and cell fate” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=519 )
Roberto Chiarle, MD; Associate Professor of Pathology, Boston Children's Hospital. "Mechanisms of genomic instability and cancer immunotherapy” (http://chiarle.tch.harvard.edu)
Christopher P. Crum, MD; Professor of Pathology, Brigham and Women’s Hospital “Pathology of gynecologic cancer prevention” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=641 )
Dora Dias-Santagata, PhD, FACMG; Assistant Professor of Pathology, MGH, “Identifying markers of response to targeted therapeutics in human cancer” (http://www.massgeneral.org/pathology/faculty/dias-santagata.aspx)
Daniela Dinulescu, PhD; Assistant Professor of Pathology, Brigham and Women's Hospital, "Early detection strategies and chemoresistance mechanisms in ovarian cancer” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=45 )
Mark D. Fleming, MD, DPhil, S. Burt Wolbach Professor of Pathology, Boston Children’s Hospital, “Molecular genetics of iron metabolism and bone marrow failure disorders.” http://www.childrenshospital.org/doctors/mark-fleming
Jonathan A. Fletcher, MD; Associate Professor of Pathology, Brigham and Women’s Hospital, "Oncogenic mechanisms and targeted therapies in pediatric and adult sarcoma” (https://connects.catalyst.harvard.edu/Profiles/display/Person/28166 )
Christopher French, MD; Associate Professor of Pathology; Brigham and Women’s Hospital, "Pathogenesis and treatment of NUT midline carcinoma" (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=523 )
Gad A. Getz, PhD; Associate Professor of Pathology, MGH, “Finding cancer genes and pathways is a crucial first step towards therapy” (http://www.massgeneral.org/pathology/faculty/getz_gad.aspx)
A. John Iafrate, MD, PhD; Professor of Pathology, MGH, “Identifying actionable genetic alterations in cancer” (http://www.massgeneral.org/pathology/doctors/doctor.aspx?ID=17868)
Antoine E Karnoub, PhD; Assistant Professor of Pathology, Beth Israel Deaconess Medical Center, “Microenvironmental Regulation of Cancer Pathogenesis and Malignancy” (https://www.bidmc.org/research/research-by-department/pathology/laboratories/antoine-karnoub-lab)
Annette S. Kim, MD, PhD; Associate Professor of Pathology, Brigham and Women’s Hospital, “Mechanisms of hematopoiesis in clonal hematopoiesis and myeloid neoplasms” (https://connects.catalyst.harvard.edu/Profiles/display/Person/145645 )
David M. Langenau, PhD;Associate Professor of Pathology, MGH, “Mechanisms of progression and relapse in pediatric cancer” (www.langenaulab.com)
Long Phi Le, MD, PhD; Assistant Professor of Pathology, MGH, “Enabling clinical next-generation sequencing” (http://www.massgeneral.org/pathology/doctors/doctor.aspx?ID=18505#)
Christine G. Lian, MD; Assistant Professor of Pathology, Brigham and Women’s Hospital, “Genetic and Epigenetic Mechanisms of Skin Diseases” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=6363 )
Keith L. Ligon, MD, PhD; Associate Professor of Pathology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Children’s Hospital, “Genetics and biology of adult and pediatric brain tumors, clinical and preclinical trials” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=5800 )
Massimo Loda, MD, Professor of Pathology; Brigham and Women’s Hospital and Dana-Farber Cancer Institute, “Metabolic dependencies in prostate cancer” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=5801 )
David N. Louis, MD; Benjamin Castleman Professor of Pathology, MGH, “Enabling international approaches to molecular classification of brain tumors” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1332)
Alarice C. Lowe, MD; Assistant Professor of Pathology, Brigham and Women’s Hospital, “Clinical applications of circulating tumor cell technologies” (https://connects.catalyst.harvard.edu/Profiles/display/Person/103234 )
Adrian Marino-Enriquez, MD, PhD; Instructor of Pathology, Brigham and Women’s Hospital, “Molecular pathogenesis, biology, and therapeutic target discovery in sarcoma” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=6199 )
Matthew L. Meyerson, MD, PhD, Professor of Pathology, Brigham and Women’s Hospital and Dana-Farber Cancer Institute, “Human cancer genomes and their implications for cancer therapy” (https://connects.catalyst.harvard.edu/Profiles/display/Person/2865 )
Andrea I. McClatchey, PhD; Professor of Pathology, MGH, “Membrane: cytoskeleton dynamics in regulating signaling, morphogenesis and cancer” (http://www.massgeneral.org/cancer/research/researchlab.aspx?id=1184)
George Mutter, MD; Professor of Pathology, Brigham and Women’s Hospital, “Endometrial carcinogenesis and machine assisted diagnostics” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=397 )
Reiko Nishihara, PhD; Assistant Professor of Pathology, Brigham and Women’s Hospital, “Preventable genomic aberrations in cancer through lifestyle and diet” (https://connects.catalyst.harvard.edu/Profiles/display/Person/94350 )
Jonathan Nowak, MD, PhD; Instructor in Pathology, Brigham and Women’s Hospital, “Molecular biology of pancreatic and colorectal cancer” (https://connects.catalyst.harvard.edu/Profiles/display/Person/91012 )
Carmelo Nucera, MD, PhD; Assistant Professor of Pathology, Beth Israel Deaconess Medical Center, “Thyroid cancer, long intergenic non-coding RNA (LincRNA) and rare and orphan tumors” (http://www.bidmc.org/Research/Departments/Pathology/Laboratories/Carmelo-Nucera-Lab.aspx)
Shuji Ogino, MD, PhD; Professor of Pathology; Brigham and Women’s Hospital, “Integrating molecular pathological epidemiology, genomics, microbiology, and immunology” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=5797 )
Pier Paolo Pandolfi, MD PhD; Director, Cancer Center at Beth Israel Deaconess Medical Center, George C. Reisman Professor of Medicine, “Cell biology, cancer genetics, RNA medicine and signal transduction” (http://www.pandolfilab.org)
Dipak Panigraphy, MD; Assistant Professor of Pathology, Beth Israel Deaconess Medical Center, “Bioactive lipids in cancer” (http://www.bidmc.org/Research/Departments/Pathology/Laboratories/Dipak-Panigrahy-Lab.aspx)
Miguel N. Rivera, MD; Assistant Professor of Pathology, MGH, “Using genomics to identify critical pathways in pediatric tumors” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1310)
Scott Rodig, MD, PhD; Associate Professor of Pathology, Brigham and Women's Hospital, “Development and application of tissue biomarkers to guide cancer diagnosis and therapy” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=2884 )
Sandro Santagata, MD, PhD; Assistant Professor of Pathology; Brigham and Women’s Hospital, “Identifying therapeutic targets for adult and pediatric brain tumors” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=35 )
Sunita Setlur, PhD; Brigham and Women’s Hospital, “Genetic and epigenetic mechanisms of progression in ovarian and prostate cancers” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=5788 )
Dennis C. Sgroi, MD; Professor of Pathology, MGH, “Molecular pathogenesis of human breast cancer” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1286)
Arlene H. Sharpe, MD, PhD; George Fabyan Professor of Comparative Pathology, Brigham and Women’s Hospital, "Regulation of immune responses by T cell costimulatory and coinhibitory pathways in health and disease" (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=40 )
Sabina Signoretti, M.D., Associate Professor of Pathology, Brigham and Women’s Hospital, “Molecular mechanisms underlying the development of genitourinary malignancies” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=237 )
Matthew Stachler, MD, PhD; Instructor in Pathology; Brigham and Women’s Hospital, “Molecular mechanisms that drive pre-neoplastic progression” (https://connects.catalyst.harvard.edu/Profiles/display/Person/71481 )
Anat Stemmer-Rachamimov, MD; Associate Professor of Pathology, MGH, “Investigating hereditary brain tumor syndromes” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1309)
Mario L. Suvà, MD, PhD; Assistant Professor of Pathology, MGH, “Leveraging single-cell profiling to dissect the biology of brain tumors” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1600)
Alex Toker, PhD; Professor of Pathology, Chief Division of Signal Transduction, Beth Israel Deaconess Medical Center, “Signaling pathways and cell metabolism in cancer initiation and progression” (http://www.tokerlab.com)
David R. Walt, PhD; Professor of Pathology, Brigham and Women’s Hospital, “Ultrasensitive diagnostics applied to pressing healthcare problems” (https://connects.catalyst.harvard.edu/Profiles/display/Person/160170 )
Wenyi Wei, PhD; Professor of Pathology, Beth Israel Deaconess Medical Center, “Cell signaling pathways in cell cycle regulation and tumorigenesis” (http://www.hms.harvard.edu/dms/BBS/fac/Wei.php)
Chin-Lee Wu, MD, PhD; Associate Professor of Pathology, MGH, “Molecular basis of human urologic tumors” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1315)
Ömer H. Yilmaz, MD PhD; Instructor in Pathology, MGH, “Connections between diet, physiology, and stem cells in regeneration and cancer” (https://ki.mit.edu/people/faculty/yilmaz)
Giorgia Zadra, Instructor in Pathology, Brigham and Women’s Hospital and Dana-Farber Cancer Institute, “Targeting and imaging the metabolic vulnerabilities of prostate cancer” (https://connects.catalyst.harvard.edu/Profiles/display/Person/6774 )
Lee Zou, PhD; Professor of Pathology, MGH, “Cellular responses to chromosomal insults and maintenance of genomic stability” (http://www.massgeneral.org/cancer/research/researchlab.aspx?id=1198)
Cardiovascular
Michael A. Gimbrone, Jr., M.D.; Professor of Pathology, Brigham and Women’s Hospital, “Vascular endothelium in health and disease” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=525 )
Petr Jarolim, MD, PhD; Professor of Pathology, Brigham and Women’s Hospital, “Use of cardiovascular biomarkers for prediction of adverse events” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=53 )
Andrew Lichtman, MD, PhD; Professor of Pathology, Brigham and Women’s Hospital, “Immunopathology of cardiovascular disease” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=654 )
Bill Luscinskas, PhD, Professor of Pathology, Brigham and Women’s Hospital, “Endothelial and immune cell communication in CVD and cancer” (http://fwl.bwh.harvard.edu/ )
Richard N. Mitchell, MD, PhD; Professor of Pathology, Brigham and Women’s Hospital, "Pathobiology of vascular intimal hyperplasia and aneurysm formation" (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=57 )
Robert Padera, MD, PhD; Brigham and Women’s Hospital, “Biomaterial-tissue interactions, drug delivery and medical device pathology” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=5798 )
Frederick J. Schoen, MD, PhD; Professor of Pathology and Health Sciences and Technology, Brigham and Women’s Hospital, “Mechanisms of native and prosthetic heart valve pathology, and substitute valve development” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=37 )
Astrid Weins, MD, PhD; Assistant Professor of Pathology, Brigham and Women’s Hospital, “Mechanisms of glomerular injury and disease progression in podocytopathies” (https://connects.catalyst.harvard.edu/Profiles/display/Person/52981 )
Computational Biology, Genomics and Epigenomics
Martin Aryee, PhD; Assistant Professor of Pathology, MGH, “Computational methods for genomics and epigenomics” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1555)
Anne B.S. Giersch, Ph.D., Assistant Professor of Pathology, Brigham and Women’s Hospital, “Genetic causes of hearing loss”(https://connects.catalyst.harvard.edu/Profiles/display/Person/53534)
John M. Higgins, MD; Assistant Professor of Systems Biology, MGH, “Developing mathematical descriptions of complex human disease phenotypes” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1305)
Michael S. Lawrence, PhD; Assistant Professor of Pathology, MGH, “Understanding mutagenic processes and identifying mutations that drive cancer” (http://www.massgeneral.org/cancer/research/researchlab.aspx?id=1740)
Cynthia Casson Morton, Ph.D.; Professor of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women’s Hospital; “Human genetics and genomics of normal and diseased states” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=394 )
Luca Pinello, PhD; Assistant Professor of Pathology, MGH, “Computational methods for epigenomics, genome editing and single cell analysis” (http://www.pinellolab.org/)
Heidi L. Rehm, PhD, FACMG; Associate Professor of Pathology, Brigham and Women’s Hospital, “Discovering and cataloging the role of genomic variation in human disease” (https://connects.catalyst.harvard.edu/Profiles/display/Person/16636 )
Hanno Steen, PhD; Associate Professor of Pathology, Boston Children’s Hospital, “Proteomics to understand and diagnose inflammation, infection and CNS disease” (http://www.childrenshospital.org/research-and-innovation/research/labs/steen-laboratory)
Digestive Systems / Microbiome
Lynn Bry, MD, PhD; Associate Professor of Pathology, Brigham and Women’s Hospital, “Host-commensal-pathogen interactions, microbiome mediated immunomodulation, genetics of the Clostridiales” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=244 )
Georg Gerber, MD, PhD; Assistant Professor of Pathology, Brigham and Women’s Hospital, “Computational and high-throughput methods for microbiome research” (http://gerber.bwh.harvard.edu )
James E Kirby, MD; Associate Professor of Pathology, Beth Israel Deaconess Medical Center, “Antimicrobial discovery, novel diagnostics and bacterial pathogenesis” http://www.kirbylab.org
Andrew Onderdonk, PhD; Professor of Pathology; Brigham and Women’s Hospital, “The role of the human microbiome in health and disease” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=655 )
Emerging Technologies
Guillermo J. Tearney, MD, PhD; Professor of Pathology, MGH, “Non-invasive, high-resolution optical imaging methods for disease diagnosis” (www.tearneylab.org)
J. Keith Joung, MD, PhD; Professor of Pathology, MGH, “CRISPR-Cas genome editing technologies for research and gene therapy” (www.jounglab.org)
Immunity, Immunobiology, and Inflammation
Ramy Arnout, MD, DPhil; Assistant Professor of Pathology, Beth Israel Deaconess Medical Center, “B-cell and T-cell repertoires, clinical informatics” (http://arnaoutlab.org)
Atul K. Bhan, MBBS, MD; Professor of Pathology, MGH, “Researching mucosal immunology and inflammatory bowel disease” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1289)
Manfred Brigl, MD, PhD, Assistant Professor of Pathology; Brigham and Women’s Hospital, “Role and function of innate T cells in inflammation and immunity to infection” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=240 )
Robert B. Colvin, MD; Benjamin Castleman Distinguished Professor of Pathology, MGH, “Pathogenesis of rejection and tolerance of organ transplants” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1308)
Bruce Horwitz, MD, PhD; Brigham and Women’s Hospital, “Transcriptional regulation of mucosal inflammatory responses” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=48)
Lester Kobzik, MD; Professor of Pathology, Brigham and Women’s Hospital, "Innate immunity and host defense in the lung" (https://connects.catalyst.harvard.edu/Profiles/display/Person/37208 )
Vinay S. Mahajan MD, PhD, Instructor of Pathology; Brigham and Women’s Hospital, “Pathogenesis of fibrotic disorders” (https://connects.catalyst.harvard.edu/Profiles/display/Person/74915 )
Tanya N. Mayadas, PhD; Professor of Pathology, Brigham and Women’s Hospital, “Innate immune and endothelial cell dependent mechanisms of inflammation” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=54 )
Frederic I. Preffer, PhD; Professor of Pathology, MGH, “Immunophenotype and functional capacity of tissue stem cells” (https://researchcores.partners.org/flow/about)
Eric S. Rosenberg, MD; Associate Professor of Pathology, MGH, “Mechanisms of CD4 cell dysfunction in persons with acute HIV infection” http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1311
Rex Neal Smith, MD, PhD; Professor of Pathology, MGH, “Investigating the causes of acute and chronic rejection” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1313)
Catherine T Yan, PhD; Assistant Professor of Pathology, Beth Israel Deaconess Medical Center, “DNA repair, cancer genetics, signal transduction, immunology and stem cell biology” (https://www.hms.harvard.edu/dms/bbs/fac/Yan.php)
Metabolism
Anders H Berg, MD PhD; Assistant Professor of Pathology and Assistant Medical Director of Clinical Chemistry, Beth Israel Deaconess Medical Center, “The pathophysiology of uremia in kidney disease” (https://connects.catalyst.harvard.edu/Profiles/display/Person/44230)
Neuroscience
Matthew P Anderson, MD PhD; Associate Professor of Pathology, Beth Israel Deaconess Medical Center, “Molecular, cellular and network mechanisms in the central nervous system” (http://www.bidmc.org/Research/Departments/Pathology/Laboratories/Matthew-Anderson-Laboratory.aspx)
Ginam Cho, PhD, Instructor of Pathology; Brigham and Women’s Hospital, "Regulation mechanism of ER-mitochondria contact in neuroscience" (https://connects.catalyst.harvard.edu/Profiles/display/Person/116258 )
Mel Feany, MD, PhD, Professor of Pathology; Brigham and Women’s Hospital, “Cellular and molecular mechanisms of neurodegeneration” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=247 )
Matthew P. Frosch, MD, PhD; Lawrence J. Henderson Associate Professor of Pathology and Health Sciences & Technology, MGH, “Animal models of human neurodegenerative diseases” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1306)
Jeffery Golden, MD, Professor of Pathology; Brigham and Women’s Hospital, “Mechanisms of neurodevelopment and neurodevelopment disorders”. (https://connects.catalyst.harvard.edu/Profiles/display/Person/106174 )
John Hanna, MD PhD; Assistant Professor of Pathology, Brigham and Women’s Hospital, “Basic mechanisms of protein degradation; cellular response to misfolded proteins” (https://connects.catalyst.harvard.edu/Profiles/display/Person/67558 )
Hannah C. Kinney, MD; Professor of Pathology, Boston Children’s Hospital, "Potential brain mechanisms of sudden, unexpected, and unexplained death across the entire pediatric age spectrum." (http://www.childrenshospital.org/researchers/hannah-kinney)
Maria K. Lehtinen, PhD; Assistant Professor of Pathology, Boston Children’s Hospital, “Choroid plexus-cerebrospinal fluid system biology” (http://www.childrenshospital.org/LehtinenLab)
Non-coding RNAs in development and disease
Jeannie T. Lee, MD, PhD; Professor of Genetics (Pathology), MGH, “The role of long noncoding RNA in epigenomic regulation” (http://www.massgeneral.org/pathology/faculty/lee.aspx)
Frank Slack, PhD; Shields Warren Mallinckrodt Professor of Medical Research, Departments of Pathology and Medicine, Beth Israel Deaconess Medical Center, “Non-coding RNAs in development, aging and disease” (http://www.bidmc.org/Research/Departments/Pathology/Laboratories/Frank-Slack-Lab.aspx)
Stem Cells and Regenerative Medicine
Guillermo García-Cardeña, PhD; Associate Professor of Pathology, Brigham and Women’s Hospital, “Biomechanical control of endothelial cell identity and function” (http://garcia-cardena.bwh.harvard.edu/ )
David Milstone, MD; Assistant Professor of Pathology; Brigham and Women’s Hospital, “Mechanisms of vascular and extraembryonic development and inflammation” (http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=56 )
George F. Murphy, MD; Professor of Pathology; Brigham and Women’s Hospital, “Cutaneous stem cell biology in immunity, cancer, and tissue regeneration” (https://connects.catalyst.harvard.edu/Profiles/display/Person/69208 )
Olivier Pourquie, PhD; Brigham and Women’s Hospital, “Development of the musculo-skeletal system” (https://connects.catalyst.harvard.edu/Profiles/display/Person/123503 )
Jun Shen, PhD, FACMG; Assistant Professor of Pathology, Brigham and Women’s Hospital; “Gene discovery, genetic diagnostics, and gene therapy for hereditary disorders” (https://connects.catalyst.harvard.edu/Profiles/display/Person/61392 )
Vascular Disease
Olivier Kocher, MD, PhD; Associate Professor of Pathology, Beth Israel Deaconess Medical Center, “Regulation of the HDL receptors and animal models of atherosclerosis” (http://www.bidmc.org/Research/Departments/Pathology/Laboratories/Olivier-Kocher-Lab.aspx)
Jack Lawler, PhD; Professor of Pathology, Vice-Chair for Research, Beth Israel Deaconess Medical Center, “The role of the thrombospondins in the tumor microenvironment” (http://www.bidmc.org/Research/Departments/Pathology/Laboratories/JackLawlerLab.aspx)
Jeffrey Saffitz, MD PhD; Mallinckrodt Professor of Pathology, HMS; Chair, Department of Pathology, Beth Israel Deaconess Medical Center, “Mechanisms of cardiac injury and sudden death in arrhythmogenic cardiomyopathy” (http://www.bidmc.org/Research/Departments/Pathology/Laboratories/Jeffrey-Saffitz-Lab.aspx)
James R. Stone, MD, PhD; Associate Professor of Pathology, MGH, “Investigating the molecular mechanisms of vascular disease” (http://www.massgeneral.org/pathology/research/researchlab.aspx?id=1314)