Paper Chase is a research database designed to offer abstracts of research articles published in journals that have a highly rated impact factor as determined by ISI Impact Factor and PageRank. Abstracts are organized by date, with the most recently published papers listed first. For a listing of HMS published papers from additional journals, visit Harvard Catalyst’s Medvane bibliome mining system.

Dopaminergic neurons inhibit striatal output through non-canonical release of GABA.

 

Squamous cell lung cancer (The Cancer Genome Atlas Research Network)

Challenging Parkinson’s dogma, dopamine may not be the only key player in this tragic neurodegenerative disease

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Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy

 

Discovery reveals important clues to cancer metastasis. Findings offer a new direction in pursuit of potential therapies for bone metastasis.

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Paper Chase

Home/Research/Paper Chase
1.

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.

Nature.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
| Apr 18, 2013
2.

Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration.

Proc. Natl. Acad. Sci. U.S.A.
Chen X, Burdett TC, Desjardins CA, Logan R, Cipriani S, Xu Y, Schwarzschild MA.
| Jan 2, 2013
3.

Treatment of Parkinson disease: a 64-year-old man with motor complications of advanced Parkinson disease.

JAMA.
Tarsy D.
| Jun 6, 2012
4.

A 64-Year-Old Man With Motor Complications of Advanced Parkinson Disease.

JAMA.
Burns RB.
| May 1, 2012
5.

The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax.

Proc. Natl. Acad. Sci. U.S.A.
Johnson BN, Berger AK, Cortese GP, Lavoie MJ.
| Apr 17, 2012
6.

Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway.

Proc. Natl. Acad. Sci. U.S.A.
Tofaris GK, Kim HT, Hourez R, Jung JW, Kim KP, Goldberg AL.
| Oct 11, 2011
7.

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation.

Nature.
Bartels T, Choi JG, Selkoe DJ.
| Sep 1, 2011
8.

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.

Cell.
Mazzulli JR, Xu YH, Sun Y, Knight AL, McLean PJ, Caldwell GA, Sidransky E, Grabowski GA, Krainc D.
| Jul 8, 2011
9.

ES cell-derived renewable and functional midbrain dopaminergic progenitors.

Proc. Natl. Acad. Sci. U.S.A.
Chung S, Moon JI, Leung A, Aldrich D, Lukianov S, Kitayama Y, Park S, Li Y, Bolshakov VY, Lamonerie T, Kim KS.
| Jun 7, 2011
10.

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.

Proc. Natl. Acad. Sci. U.S.A.
Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O.
| Sep 7, 2010
11.

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.

Proc. Natl. Acad. Sci. U.S.A.
Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ, Shen J.
| May 25, 2010
12.

Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.

Proc. Natl. Acad. Sci. U.S.A.
Chung CY, Koprich JB, Hallett PJ, Isacson O.
| Dec 29, 2009
13.

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

Proc. Natl. Acad. Sci. U.S.A.
Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J.
| Aug 25, 2009
14.

Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.

Proc. Natl. Acad. Sci. U.S.A.
Liu Z, Meray RK, Grammatopoulos TN, Fredenburg RA, Cookson MR, Liu Y, Logan T, Lansbury PT.
| Mar 24, 2009
15.

Disease-specific induced pluripotent stem cells.

Cell.
Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ.
| Sep 5, 2008
16.

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress.

Proc. Natl. Acad. Sci. U.S.A.
Gautier CA, Kitada T, Shen J.
| Aug 12, 2008
17.

GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein.

Proc. Natl. Acad. Sci. U.S.A.
Scherzer CR, Grass JA, Liao Z, Pepivani I, Zheng B, Eklund AC, Ney PA, Ng J, McGoldrick M, Mollenhauer B, Bresnick EH, Schlossmacher MG.
| Aug 5, 2008
18.

Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.

Proc. Natl. Acad. Sci. U.S.A.
Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O.
| Sep 4, 2007
19.

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.

Science.
Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG.
| Jul 27, 2007
20.

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice.

Proc. Natl. Acad. Sci. U.S.A.
Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, Shen J.
| Jul 3, 2007