Paper Chase is a research database designed to offer abstracts of research articles published in journals that have a highly rated impact factor as determined by ISI Impact Factor and PageRank. Abstracts are organized by date, with the most recently published papers listed first. 

Paper Chase

1.

Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases.

Nat. Med.
Ni J, Ramkissoon SH, Xie S, Goel S, Stover DG, Guo H, Luu V, Marco E, Ramkissoon LA, Kang YJ, Hayashi M, Nguyen QD, Ligon AH, Du R, Claus EB, Alexander BM, Yuan GC, Wang ZC, Iglehart JD, Krop IE, Roberts TM, Winer EP, Lin NU, Ligon KL, Zhao JJ.
| 06 06, 2016
2.

Phosphatase PP2A is requisite for the function of regulatory T cells.

Nat. Immunol.
Apostolidis SA, Rodríguez-Rodríguez N, Suárez-Fueyo A, Dioufa N, Ozcan E, Crispín JC, Tsokos MG, Tsokos GC.
| 03 14, 2016
3.

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.

Cell.
Chantranupong L, Scaria SM, Saxton RA, Gygi MP, Shen K, Wyant GA, Wang T, Harper JW, Gygi SP, Sabatini DM.
| Mar 24, 2016
4.

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations.

Nat. Genet.
Bueno R, Stawiski EW, Goldstein LD, Durinck S, De Rienzo A, Modrusan Z, Gnad F, Nguyen TT, Jaiswal BS, Chirieac LR, Sciaranghella D, Dao N, Gustafson CE, Munir KJ, Hackney JA, Chaudhuri A, Gupta R, Guillory J, Toy K, Ha C, Chen YJ, Stinson J, Chaudhuri S, Zhang N, Wu TD, Sugarbaker DJ, de Sauvage FJ, Richards WG, Seshagiri S.
| 02 29, 2016
5.

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.

Cell.
Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, Asara JM, Cantley LC, Wulf GM.
| Jan 28, 2016
6.

Control of proteasomal proteolysis by mTOR.

Nature.
Zhao J, Garcia GA, Goldberg AL.
| Jan 21, 2016
7.

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy.

Proc. Natl. Acad. Sci. U.S.A.
Zhao J, Zhai B, Gygi SP, Goldberg AL.
| Dec 29, 2015
8.

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth.

Cell.
Kleffel S, Posch C, Barthel SR, Mueller H, Schlapbach C, Guenova E, Elco CP, Lee N, Juneja VR, Zhan Q, Lian CG, Thomi R, Hoetzenecker W, Cozzio A, Dummer R, Mihm MC, Flaherty KT, Frank MH, Murphy GF, Sharpe AH, Kupper TS, Schatton T.
| Sep 10, 2015
9.

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Proc. Natl. Acad. Sci. U.S.A.
Kuo SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G, Dančík V, Kuballa P, Latorre I, Conway KL, Sarkar S, Maetzel D, Jaenisch R, Clemons PA, Schreiber SL, Shamji AF, Xavier RJ.
| Aug 4, 2015
10.

The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation.

Cell.
Lipton JO, Yuan ED, Boyle LM, Ebrahimi-Fakhari D, Kwiatkowski E, Nathan A, Güttler T, Davis F, Asara JM, Sahin M.
| May 21, 2015
11.

Intracellular osteopontin regulates homeostasis and function of natural killer cells.

Proc. Natl. Acad. Sci. U.S.A.
Leavenworth JW, Verbinnen B, Wang Q, Shen E, Cantor H.
| Jan 13, 2015
12.

An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma.

Proc. Natl. Acad. Sci. U.S.A.
Baratta MG, Schinzel AC, Zwang Y, Bandopadhayay P, Bowman-Colin C, Kutt J, Curtis J, Piao H, Wong LC, Kung AL, Beroukhim R, Bradner JE, Drapkin R, Hahn WC, Liu JF, Livingston DM.
| Jan 6, 2015
13.

Genetic modifiers of EGFR dependence in non-small cell lung cancer.

Proc. Natl. Acad. Sci. U.S.A.
Sharifnia T, Rusu V, Piccioni F, Bagul M, Imielinski M, Cherniack AD, Pedamallu CS, Wong B, Wilson FH, Garraway LA, Altshuler D, Golub TR, Root DE, Subramanian A, Meyerson M.
| Dec 30, 2014
14.

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.

Proc. Natl. Acad. Sci. U.S.A.
Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, Helman E, Taylor-Weiner A, McKenna A, DeLuca DS, Lawrence MS, Ambrogio L, Sougnez C, Sivachenko A, Walensky LD, Wagle N, Mora J, de Torres C, Lavarino C, Dos Santos Aguiar S, Yunes JA, Brandalise SR, Mercado-Celis GE, Melendez-Zajgla J, Cárdenas-Cardós R, Velasco-Hidalgo L, Roberts CW, Garraway LA, Rodriguez-Galindo C, Gabriel SB, Lander ES, Golub TR, Orkin SH, Getz G, Janeway KA.
| Dec 23, 2014
15.

Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.

Nat. Med.
Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, Weigert O, Kopp N, Wu SC, Kim SS, Liu H, Tivey T, Christie AL, Elpek KG, Card J, Gritsman K, Gotlib J, Deininger MW, Makishima H, Turley SJ, Javidi-Sharifi N, Maciejewski JP, Jaiswal S, Ebert BL, Rodig SJ, Tyner JW, Marto JA, Weinstock DM, Lane AA.
| 12 08, 2014
16.

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.

Proc. Natl. Acad. Sci. U.S.A.
White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM.
| Nov 4, 2014
17.

Response and acquired resistance to everolimus in anaplastic thyroid cancer.

N. Engl. J. Med.
Wagle N, Grabiner BC, Van Allen EM, Amin-Mansour A, Taylor-Weiner A, Rosenberg M, Gray N, Barletta JA, Guo Y, Swanson SJ, Ruan DT, Hanna GJ, Haddad RI, Getz G, Kwiatkowski DJ, Carter SL, Sabatini DM, Jänne PA, Garraway LA, Lorch JH.
| Oct 9, 2014
18.

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

Science.
Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG.
| Sep 26, 2014
19.

Medicine. A common pathway for a rare disease?

Science.
Vafai SB, Mootha VK.
| Dec 20, 2013
20.

Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma.

Proc. Natl. Acad. Sci. U.S.A.
Yuan P, Ito K, Perez-Lorenzo R, Del Guzzo C, Lee JH, Shen CH, Bosenberg MW, McMahon M, Cantley LC, Zheng B.
| Nov 5, 2013