Paper Chase is a research database designed to offer abstracts of research articles published in journals that have a highly rated impact factor as determined by ISI Impact Factor and PageRank. Abstracts are organized by date, with the most recently published papers listed first. For a listing of HMS published papers from additional journals, visit Harvard Catalyst’s Medvane bibliome mining system.

Dopaminergic neurons inhibit striatal output through non-canonical release of GABA.

 

Squamous cell lung cancer (The Cancer Genome Atlas Research Network)

Challenging Parkinson’s dogma, dopamine may not be the only key player in this tragic neurodegenerative disease

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Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy

 

Discovery reveals important clues to cancer metastasis. Findings offer a new direction in pursuit of potential therapies for bone metastasis.

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Paper Chase

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1.

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.

Proc. Natl. Acad. Sci. U.S.A.
Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, Livingston DM.
| May 8, 2013
2.

Integrative eQTL-based analyses reveal the biology of breast cancer risk loci.

Cell.
Li Q, Seo JH, Stranger B, McKenna A, Pe'er I, Laframboise T, Brown M, Tyekucheva S, Freedman ML.
| Jan 31, 2013
3.

Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.

Science.
Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, Concannon KF, Donaldson MC, Sequist LV, Brachtel E, Sgroi D, Baselga J, Ramaswamy S, Toner M, Haber DA, Maheswaran S.
| Feb 1, 2013
4.

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.

Proc. Natl. Acad. Sci. U.S.A.
Hirsch HA, Iliopoulos D, Struhl K.
| Jan 15, 2013
5.

Estrogen receptor prevents p53-dependent apoptosis in breast cancer.

Proc. Natl. Acad. Sci. U.S.A.
Bailey ST, Shin H, Westerling T, Liu XS, Brown M.
| Oct 30, 2012
6.

Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.

Proc. Natl. Acad. Sci. U.S.A.
Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK.
| Nov 6, 2012
7.

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.

Proc. Natl. Acad. Sci. U.S.A.
Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC.
| Oct 23, 2012
8.

Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy.

Proc. Natl. Acad. Sci. U.S.A.
El-Haibi CP, Bell GW, Zhang J, Collmann AY, Wood D, Scherber CM, Csizmadia E, Mariani O, Zhu C, Campagne A, Toner M, Bhatia SN, Irimia D, Vincent-Salomon A, Karnoub AE.
| Oct 23, 2012
9.

TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.

Proc. Natl. Acad. Sci. U.S.A.
Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L.
| Oct 9, 2012
10.

There is more to life than death.

N. Engl. J. Med.
Hartzband P, Groopman J.
| Sep 13, 2012
11.

Case records of the Massachusetts General Hospital. Case 27-2012. A 60-year-old woman with painful muscle spasms and hyperreflexia.

N. Engl. J. Med.
Byrne TN, Isakoff SJ, Rincon SP, Gudewicz TM.
| Aug 30, 2012
12.

An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state.

Proc. Natl. Acad. Sci. U.S.A.
Polytarchou C, Iliopoulos D, Struhl K.
| Sep 4, 2012
13.

Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy.

Lancet.
Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT, Alkandari JR.
| Jul 21, 2012
14.

Acetylation-dependent regulation of Skp2 function.

Cell.
Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W.
| Jul 6, 2012
15.

Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity.

Proc. Natl. Acad. Sci. U.S.A.
Sengupta P, Basu S, Soni S, Pandey A, Roy B, Oh MS, Chin KT, Paraskar AS, Sarangi S, Connor Y, Sabbisetti VS, Kopparam J, Kulkarni A, Muto K, Amarasiriwardena C, Jayawardene I, Lupoli N, Dinulescu DM, Bonventre JV, Mashelkar RA, Sengupta S.
| Jul 10, 2012
16.

Case records of the Massachusetts General Hospital. Case 16-2012. A 32-year-old woman with HER2-positive breast cancer.

N. Engl. J. Med.
Baselga J, Smith BL, Rafferty EA, Bombonati A.
| May 24, 2012
17.

Progress in breast cancer research.

Proc. Natl. Acad. Sci. U.S.A.
Polyak K, Vogt PK.
| Feb 21, 2012
18.

Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial.

Lancet.
Baselga J, Bradbury I, Eidtmann H, Di Cosimo S, de Azambuja E, Aura C, Gómez H, Dinh P, Fauria K, Van Dooren V, Aktan G, Goldhirsch A, Chang TW, Horváth Z, Coccia-Portugal M, Domont J, Tseng LM, Kunz G, Sohn JH, Semiglazov V, Lerzo G, Palacova M, Probachai V, Pusztai L, Untch M, Gelber RD, Piccart-Gebhart M, Lerzo G.
| Feb 18, 2012
19.

Clinical problem-solving. Breathless.

N. Engl. J. Med.
Gavin MC, Morse D, Partridge AH, Levy BD, Loscalzo J.
| Jan 5, 2012
20.

Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer.

N. Engl. J. Med.
Baselga J, Campone M, Piccart M, Burris HA, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, Beck JT, Ito Y, Yardley D, Deleu I, Perez A, Bachelot T, Vittori L, Xu Z, Mukhopadhyay P, Lebwohl D, Hortobagyi GN.
| Feb 9, 2012