Paper Chase is a research database designed to offer abstracts of research articles published in journals that have a highly rated impact factor as determined by ISI Impact Factor and PageRank. Abstracts are organized by date, with the most recently published papers listed first. 

Paper Chase

1.

High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.

Nature.
Kleinstiver BP, Pattanayak V, Prew MS, Tsai SQ, Nguyen NT, Zheng Z, Joung JK.
| Jan 28, 2016
2.

In vivo gene editing in dystrophic mouse muscle and muscle stem cells.

Science.
Tabebordbar M, Zhu K, Cheng JK, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ.
| Jan 22, 2016
3.

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

Science.
Nelson CE, Hakim CH, Ousterout DG, Thakore PI, Moreb EA, Castellanos Rivera RM, Madhavan S, Pan X, Ran FA, Yan WX, Asokan A, Zhang F, Duan D, Gersbach CA.
| Jan 22, 2016
4.

Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.

Nat. Genet.
Zhang X, Choi PS, Francis JM, Imielinski M, Watanabe H, Cherniack AD, Meyerson M.
| 12 14, 2015
5.

Rationally engineered Cas9 nucleases with improved specificity.

Science.
Slaymaker IM, Gao L, Zetsche B, Scott DA, Yan WX, Zhang F.
| Jan 1, 2016
6.

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Cell.
Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J.
| Dec 3, 2015
7.

Genome-wide inactivation of porcine endogenous retroviruses (PERVs).

Science.
Yang L, Güell M, Niu D, George H, Lesha E, Grishin D, Aach J, Shrock E, Xu W, Poci J, Cortazio R, Wilkinson RA, Fishman JA, Church G.
| Nov 27, 2015
8.

Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.

Cell.
Zetsche B, Gootenberg JS, Abudayyeh OO, Slaymaker IM, Makarova KS, Essletzbichler P, Volz SE, Joung J, van der Oost J, Regev A, Koonin EV, Zhang F.
| Oct 22, 2015
9.

CDK7-dependent transcriptional addiction in triple-negative breast cancer.

Cell.
Wang Y, Zhang T, Kwiatkowski N, Abraham BJ, Lee TI, Xie S, Yuzugullu H, Von T, Li H, Lin Z, Stover DG, Lim E, Wang ZC, Iglehart JD, Young RA, Gray NS, Zhao JJ.
| Sep 24, 2015
10.

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.

Nat. Med.
Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT.
| 09 21, 2015
11.

Crystal Structure of Staphylococcus aureus Cas9.

Cell.
Nishimasu H, Cong L, Yan WX, Ran FA, Zetsche B, Li Y, Kurabayashi A, Ishitani R, Zhang F, Nureki O.
| Aug 27, 2015
12.

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

N. Engl. J. Med.
Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M.
| Sep 3, 2015
13.

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.

Cell.
Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, Zhang F, Hacohen N, Regev A.
| Jul 30, 2015
14.

Engineered CRISPR-Cas9 nucleases with altered PAM specificities.

Nature.
Kleinstiver BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z, Gonzales AP, Li Z, Peterson RT, Yeh JR, Aryee MJ, Joung JK.
| Jul 23, 2015
15.

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.

Nat. Med.
Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH.
| 06 15, 2015
16.

RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.

Cell.
Pefanis E, Wang J, Rothschild G, Lim J, Kazadi D, Sun J, Federation A, Chao J, Elliott O, Liu ZP, Economides AN, Bradner JE, Rabadan R, Basu U.
| May 7, 2015
17.

In vivo genome editing using Staphylococcus aureus Cas9.

Nature.
Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F.
| Apr 9, 2015
18.

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.

Nat. Genet.
Liao J, Karnik R, Gu H, Ziller MJ, Clement K, Tsankov AM, Akopian V, Gifford CA, Donaghey J, Galonska C, Pop R, Reyon D, Tsai SQ, Mallard W, Joung JK, Rinn JL, Gnirke A, Meissner A.
| 03 30, 2015
19.

Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.

Cell.
Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA.
| Mar 12, 2015
20.

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.

Nature.
Konermann S, Brigham MD, Trevino AE, Joung J, Abudayyeh OO, Barcena C, Hsu PD, Habib N, Gootenberg JS, Nishimasu H, Nureki O, Zhang F.
| Jan 29, 2015