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Gridlock, a localized heritable vascular patterning defect in the zebrafish.
Nat. Med..11 1, 1995;1(11):1143-7.
Weinstein BM, Stemple DL, Driever W, Fishman MC.
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA.
We are using the zebrafish, Danio rerio, to identify genes that generate and pattern the vertebrate vasculature. We have isolated a recessive mutation, gridlockm145 (grlm145) in which blood flow to the tail is impeded by a localized vascular defect. Using a novel microangiographic method, we show that the blockade is in the anterior trunk, where the paired lateral dorsal aortae normally merge to form the single midline aorta. Arterial-venous shunts and collateral vessels develop in most mutant embryos, bypassing the lesion and reconstituting caudal blood flow. The grl defect resembles coarctation of the aorta, a human congenital cardiovascular malformation of unknown aetiology, in the location of the lesion and its consequences and in the mutants' dependence on collateral vessels for survival.