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Home/Research/Paper Chase/An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2.
An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2.
Nature.10 4, 1987;329(6142):840-2.
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
Recently the human T cell erythrocyte receptor CD2 has been shown to bind human erythrocytes through LFA-3, a heavily glycosylated surface protein of broad tissue distribution. CD2-LFA-3 interactions are important for cytolytic conjugate formation, for thymocyte adhesion, and for T cell activation. A complementary DNA clone encoding LFA-3 was isolated using a complementary DNA clone encoding LFA-3 was isolated using a novel transient expression system of mouse cells. The cDNA encodes a phospholipid-linked membrane protein whose extracellular domain shares significant homology with CD2. As CD2 is homologous with the neural cell adhesion molecule NCAM in immunoglobulin-like domains, cellular adhesion molecules in both neural and lymphoid tissues could have a common ancestor.