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Antibodies to CD4 in individuals infected with human immunodeficiency virus type 1.
Proc. Natl. Acad. Sci. U.S.A..5 1, 1989;86(9):3346-50.
Kowalski M, Ardman B, Basiripour L, Lu YC, Blohm D, Haseltine W, Sodroski J.
Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, MA 02115.
The attachment of human immunodeficiency virus type 1 (HIV-1) to target cells is mediated by a specific interaction between the viral envelope glycoprotein (gp120) and the CD4 receptor. Here we report that approximately 10% of HIV-1-infected individuals produce antibodies that recognize the extracellular portion of the CD4 molecule. Carboxyl-terminal deletions of CD4 that do not affect HIV-1 gp120 binding eliminate recognition of CD4 by patient antisera. In contrast, mutations in the amino-terminal domain of CD4 that attenuate HIV-1 gp120 binding do not diminish CD4 recognition by patient antisera. These results suggest that HIV-1 infection can generate antibodies directed against a region of the viral receptor distinct from the virus-binding domain.