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This message will self-destruct: NMD regulates axon guidance.
Cell.Jun 6, 2013;153(6):1185-7.
Preitner N, Quan J, Flanagan JG.
Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
The navigation of axons to their final destination can involve a sequence of steps that require different sets of guidance receptors. In this issue, Colak et al. show that regulated intra-axonal protein synthesis coupled to nonsense-mediated mRNA decay (NMD) controls a switch in Robo3.2 expression that is critical for navigation.