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Comment on "Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters".
Science.Apr 19, 2013;340(6130):273.
Ferrari F, Jung YL, Kharchenko PV, Plachetka A, Alekseyenko AA, Kuroda MI, Park PJ.
Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Conrad et al. (Reports, 10 August 2012, p. 742) reported a doubling of RNA polymerase II (Pol II) occupancy at X-linked promoters to support 5' recruitment as the key mechanism for dosage compensation in Drosophila. However, they employed an erroneous data-processing step, overestimating Pol II differences. Reanalysis of the data fails to support the authors' model for dosage compensation.