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Home/Research/Paper Chase/Genetic defect in biosynthesis of the precursor form of the fourth component of complement.
Genetic defect in biosynthesis of the precursor form of the fourth component of complement.
Science.Jan 6, 1978;199(4324):69-70.
Hall RE, Colten HR.
Ina Sue Perlmutter Cystic Fibrosis Center, Children's Hospital Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Under cell-free conditions, liver polysomes from guinea pigs genetically deficient in the fourth component of complement (C4) did not synthesize pro-C4 (the precursor of C4), but did synthesize nascent C4 polypeptides which remained polysome bound. The defect was specific for pro-C4 synthesis since the amounts of total protein and albumin synthesis and release from C4-deficient polysomes were similar to that in normal guinea pig liver polysomes.