HMS Core Facilities

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Core scientific facilities support innovative research at Harvard by providing highly specialized services, equipment and staff that would otherwise be too expensive for a single laboratory or department to provide. Below is a list of the HMS Quad Department Core Facilities.

For a more extensive listing of core facilities, use the database eagle-i.net. This open-source search application allows researchers to find resources within the Harvard community and throughout a network of 27 institutions across the U.S. Resources include core laboratories services, instruments, organisms, reagents, antibodies, cell lines, plasmids, biospecimens, algorithms, and human studies.

While most cores are publicly available, some are required by their sponsors to limit access and to differentiate pricing. Policies regarding services, access, fees and prioritization vary by core and by institution. Please contact the core facility directly for more information. 

HMS Quad Department Core Facilities

Cell Biology Molecular Electron Microscopy Facility

The HMS Molecular Electron Microscopy Facility offers scientists service, technical expertise, and instrumentation for conventional electron microscopy techniques. Training in electron microscope operation and guidance for electron microscopy projects.
Core Manager: Zongli Li
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Cell Biology Conventional Electron Microscopy Faciltiy

The Harvard Medical School EM Facility is a fee-for-service core facility open to researchers in the HMS Quadrangle and the Longwood Medical area. The Facility provides services and supervision in Transmission Electron Microscopy.
Facility Contact: Maria Ericsson
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Genetics Microscopy Facility

The facility provides the use of Confocal and 2 Photon microscopes. Although it serves primarily the Department of Genetics, other quad members are given access when needed. Please contact Kristen Bearce Lee (kbearce@genetics.med.harvard.edu) for more information.

Harvard NeuroDiscovery Center (HNDC) Enhanced Neuroimaging Core

The Core provides access to advanced confocal, multi-photon and live cell imaging microscopes and specializes in various forms of fluorescence, brightfield, DIC (Differential Interference Contrast) and live cell imaging. The facility offers users comprehensive service on confocal imaging, protocol design and microscopy training as well as digital image analysis, including consultation and custom macro program (ImageJ and Metamorph) design.
Facility Manager: Lai Ding
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Microbiology and Immunobiology BL2+ Imaging Facility

The BL2+ Imaging Facility provides the infrastructure and expertise for In-Vivo imaging of host pathogen interactions in infected mice.
Faculty Director: Uli von Andrian

Neurobiology Imaging Facility

The facility offers a wide-range of optical imaging equipment as well as technical and analytical support. The imaging equipment ranges from wide-field to confocal to super-resolution imaging through STORM technology.
Senior Imaging Specialist: Michelle Ocana
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The Nikon Imaging Center at Harvard Medical School (NIC@HMS)

The NIC is a core light microscopy facility developed in partnership with Nikon Instruments Inc. and Micro Video Instruments Inc. The NIC@HMS maintains a wide range of light microscopy stations, including laser scanning confocal, spinning disk confocal, TIRF, STORM super-resolution, FRAP/photoactivation and more. All users are trained to use the equipment; no prior imaging experience is necessary. The NIC@HMS also offers an extensive educational program, including hands-on workshops for theoretical and practical training on light microscopy techniques.
Facility Director: Jennifer Waters
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Systems Biology Microscopy Faciltiy

(SBMF) is a core facility for light microscopy developed in partnership with Nikon Instruments Inc. and Micro Video Instruments Inc. The SBMF maintains laser scanning confocals, spinning disk confocals, a total internal fluorescence system, and other basic fluorescence and transmitted light microscopes. All users are offered training to use the equipment; no prior imaging experience is necessary.
Facility Director: Jennifer Waters
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The Image and Data Analysis Core (IDAC)

IDAC provides image data analysis services to individual labs and core facilities at Harvard Medical School, including the ICCB-Longwood Screening Facility (ICCB-L), the Drosophila RNAi Screening Center (DRSC), and the Nikon Imaging Center (NIC).
Facility Directors: Hunter Elliott and Tiao Xie
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HMS Mouse Imaging Core

The HMS Mouse Imaging Core provides access for researchers to in-vivo mouse imaging for endpoint and longitudinal studies using either luminescent or fluorescent reporters in an Animal Biosafety Level 2 environment.   Staff from the ICCB-Longwood Screening Facility oversee the IVIS (In-Vivo Imaging System) Lumina II mouse imager and its use, while the IVIS room is operated and maintained by the HCCM (Harvard Center for Comparative Medicine).  Staff members provide access and training for the imager and data analysis computers, while the HCCM oversees all room and animal operations including facility access, safety training and orientation, animal transfers and husbandry, and protocol approval.
Facility Contact Info.: iccbl_ivis@hms.harvard.edu; or 617-432-5815 (the ICCB-Longwood Screening Facility)
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HSPH Bioinformatics Core (HBC)

In an effort to provide bioinformatics analysis services and training to the HMS Community, the HMS Tools and Technology Program has provided additional support and resources to the HSPH Bioinformatics Core (HBC). HBC provides expertise in areas such as array analysis, next-gen sequencing (NGS) and functional analysis. Their NGS support includes epigenetics, transcriptomics and re-sequencing studies. HBC works together with research computing groups on all aspects of data management.
Facility Contact: Meeta Mistry
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BCMP SBGrid Computing Core and Software Consortium

SBGrid Core team provides research computing support to 20 structural biology laboratories in Boston area. The SBGrid Consortium provides structural biologists worldwide with access to the computing resources they need to discover the shapes of the molecules of life. The Consortium includes X-ray crystallography, NMR and electron microscopy laboratories worldwide. Members share the costs of SBGrid's support services and gain access to a large collection of scientific applications and extensive computing resources.
Faculty Director: Piotr Sliz
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Longwood Medical Area (LMA) CyTOF Core Facility

The Longwood Medial Area (LMA) CyTOF Core Facility uses innovative technology available to the Harvard Medical School Community that integrates Mass Spectrometry with Flow Cytometry. The heart of the facility is a CyTOF®2 Mass Cytometer that is capable of analyzing, at the single cell level, up to 40 markers simultaneously with minimal signal overlap. The facility has both a dedicated operator and a data analyst who assist investigators as they design assays, process samples, and analyze the high dimensional data produced by the CyTOF. For more information and to access the core facility please contact the CyTOF Operator. 
LMA CyTOF Operator: Nicole Carlson - E: nicole_carlson@dfci.harvard.edu - T:617-632-6561
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Microbiology and Immunobiology Flow Cytometry Facility

The Flow Cytometry Facility provides flow cytometric analysis and cell sorting services to investigators in the Harvard Medical School and in the Harvard affiliated hospitals and institutions. The facility currently has a FACSCalibur and a LSRII with a high throughput sampler for assisted as well as unassisted flow cytometric acquisition and analysis, and a FACSAria for cell sorting (performed by an expert technician).
Faculty Director: Christophe Benoist
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Systems Biology FACS Facility

The Systems Biology FACS facility houses two state-of-the-art BD analyzers with high-throughput capability, a high-speed BD cell sorter with an automatic plate deposition unit, a Stratedigm analyzer with high-throughput capability, and both Mac and PC workstations for data analysis. Sorting services are offered through the facility, as well as instrument and software training. Instruments include a BD FACSCalibur (488nm/635nm; 4-color), BD SORP LSRII with HTS (405nm/488nm/594nm; 12-color), A Stratedigm S100EX with plate reader and liquid dispensing capabilities (405nm, 488nm, 561nm, and 640nm; 13 color), and a BD FACSAria IIu (405nm/488nm/633nm; 9-color). Data analysis software available at the facility includes ModFit, FlowJo, Diva 6.1.3, and CellQuestPro.
Facility Director: Jodene Moore
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HMS Microfluidics Core

The HMS Microfluidics Facility aims to make the tools of microfabrication and microfluidics available to all HMS users. Microfluidics has the potential to do for biology what microprocessors have done for computational sciences by integrating complex chemical and biological processes into one chip, facilitating the study of complex biological systems. 
Facility Manager: Calixto Saenz 
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The Drosophila RNAi Screening Center (DRSC) at Harvard Medical School

The mission of the DRSC is to provide the community with RNAi reagent libraries and a screening platform for high-throughput screens in Drosophila cultured and primary cells. Also included at the DRSC is the Trangenic RNAi Project (TRiP), the mission of the TRiP is to generate validated in vivo fly stocks for tissue-specific gene knockdown in whole animals. We provide access to information, protocols, data and software tools via our DRSC and TRiP website and underlying FlyRNAi database. The DRSC also provides access to state-of-the-art instrumentation for high-throughput, high-content fluorescence confocal imaging.
Facility Director: Stephanie Mohr
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ICCB-Longwood Screening Facility (ICCB-Longwood)

The ICCB-Longwood Investigator Initiated Screening Program assists academic researchers in carrying out high-throughput screens of chemical and RNAi libraries to identify new tools for biological research. The ICCB-Longwood compound collection is continuously growing. Over 250,000 compounds are currently available for screening, including > 8,000 'known bioactive' compounds many of which have been characterized in animal models or in the clinic. Multiple human and mouse whole-genome siRNA libraries, as well as miRNA mimic and inhibitor libraries, are available for RNAi screening. The facility employs a staff-assisted screening model.
Facility Director: Dr. Caroline Shamu
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Cell Biology Frog Facility

The Harvard Medical School amphibian facility maintains and provides aquatic research animals for a variety of scientific research. This facility is considered a satellite facility of the Harvard Center for Comparative Medicine and is regulated under their authority. The facility is restricted to those who are on IACUC approved animal research protocols for amphibians and who have undergone HCCM and facility specific training. It is run on a per animal recharge basis.
Facility Contact: Brian Frederick bfrederick@hms.harvard.edu

DF/HCC Rodent Histopathology Core

The Rodent Histopathology Core is a Dana Farber/Harvard Cancer Center facility that is based at HMS. Services that the Core provides focus mainly on mouse histopathology, and include necropsy, phenotyping of organs and tissues, dissection and tissue processing, and one-on-one consultation. The facility also generates unstained paraffin and frozen sections to be used for immunohistochemistry. The core provides individual and group training sessions for postdoctoral fellows and graduate students on the development, phenotyping and characterization of animal models of cancers.
Contact: Li Zhang
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DF/HCC DNA Resource Core

The DF/HCC DNA Resource Core was established in the spring of 1999 to meet a growing need for DNA sequencing services at a cost that is affordable for academic labs. The services that we offer to users within the Dana Farber Harvard Cancer Center and the broader scientific community include DNA sequencing for large- and small-scale projects and plasmid & distribution. Our highest priorities are quality assurance, user support and timely request fulfillment.
Faculty Director: Wade Harper
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Genome Engineering Production Group

The Genome Engineering Production Group (GEPG) was established in 2013 with the goal of facilitating genome engineering-based research through the availability of reasonably priced tools. The GEPG currently offers custom TALEN and CRISPR nuclease constructs for use in engineering human and mouse cells, as well as for model organisms including zebrafish, C. elegans, and Drosophila.  We also offer TALE-based transcriptional activator constructs.
Contact: Gerald Marsischky, PhD
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Department of Genetics Biopolymer/Next Gen Sequencing Facility

Core Instruments and Services offered: AB 3730xl - Sanger DNA Sequencing and Fragment Analysis; AB7900HT - QPCR Assays; Agilent Bioanalyzer & TapeStation - DNA and RNA Quality Assessment; Hamilton StarPlus Robot - Automation Services; Illumina HiSeq2000 & MiSeq - Next-gen Sequencing and Library Construction Services; Luminex LS200 - XMap Assays; QiaCube - Sample Preparation (DNA and RNA); and an Oligonucleotide Ordering Program; Reagents and Supplies Stock Room Program. A Comprehensive web based Laboratory Information Management System (LIMS), provides facility users with access to order services, supplies, retrieve data, review invoices and make payments online.
Facility Director: Robert Steen
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The Thermo Fisher Center for Multiplexed Proteomics (TCMP)

The Thermo Fisher Center offers proteome-wide protein expression profiling. The Center uses recently-introduced high resolution mass spectrometers (Orbitrap Fusion Tribrid) and isobaric tandem mass tags (TMT) to quantify protein expression from cells or tissues. Currently the tandem mass tag technology allows for the analysis of 6-10 samples within a single experiment.  For example, protein expression in a cancer cell line can be profiled after nine drug treatments and compared to an untreated sample across >6,000 proteins.  The services are provided to the HMS community as well as external users.
Core Director: Ryan Kunz, PhD
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BCMP Small Molecule NMR Facility

The East Quad NMR Faciltiy (EQNMR) is a core facility for small molecule NMR spectroscopy. The EQNMR Lab houses state-of-the-art 600 and 400MHz NMR systems capable of conducting multi-dimensional experiments on Natural Products and medicinal chemistry type samples. Training is provided to enable investigators to run their own experiments in a highly automated, user- friendly environment.
Core Director: Greg Heffron
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Cell Biology Taplin Biological Mass Spectrometry Facility

The Taplin Biological Mass Spectrometry facility provides mass spectrometry services to members of the HMS community as well as external users.
Faculty Director: Steve Gygi, PhD
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Microbiology and Immunobiology Biological Chemistry Mass Spec Facility

Instrumentation for this facility includes an Agilent 6520 Accurate-Mass quadrupole time-of-flight (Q-TOF) LC/MS system with great mass accuracy, mass resolution, and sensitivity for small molecule mass identification/quantitation and metabolomics experiments.  It is equipped with an Agilent 1200 series HPLC with DAD UV/V is detection for normal flow LC/MS and nitrogen CID for MS/MS.  The Q-TOF LC/MS is located in laboratory of Dr. Suzanne Walker in the Department of Microbiology and Immunobiology.
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Systems Biology Machine Shop

The Machine Shop provides: 1) design and construction of custom tools for medical research, and 2) repair of existing Scientific laboratory instruments.
Contact: Jim Horn or Jason Marchionna
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The Research Instrumentation Core Facility

The Research Instrumentation Core Facility enables the development of new scientific instruments in order to further research at Harvard Medical School and affiliated institutions.  The facility provides consultations on the design of hardware or software, purchasing decisions, and assistance with implementation.  The staff will work with researchers to develop and fabricate customized electronic, optical, and mechanical devices, as well as software interfaces for these devices.  Furthermore, the facility provides tools and workshop space for authorized researchers to design and prototype their own instruments.  The facility is staffed by a full-time Neurobiology device engineer and a staff engineer. 
Facility Contact: Ofer Mazor at ofer_mazor@hms.harvard.edu

Research Imaging Solutions for Scientific Communication 

Preparing images for inclusion in scientific communication has long been a time-consuming, confusing and often frustrating endeavor. Research Imaging Solutions works to identify ways to streamline image preparation so researchers can maximize their time at the bench, writing grants and developing discoveries.

Research Imaging Solutions services are available to all Harvard, HMS, HSDM, HSPH and affiliated hospital employees. Expertise can be accessed in a way that acknowledges each kind of learning style: one-on-one consulting; workshop and seminars and online easy-to-follow guides and recipes. The accessibility and convenience of this Quad-centered service is supplemented by substantial web-based assistance at it.med.harvard.edu/ris, making Research Imaging Solutions a 24/7 resource.

Training
RIS skills training is based on the unique ways that researchers use proprietary scientific applications, Microsoft Office and a variety graphics programs to create, acquire and edit images that are included in grant applications, journal articles and presentations to the scientific community. Half-day workshops are free and address the specific imaging and presentation needs of researchers. Lunchtime Seminars are presented at no charge and cover topics including poster making, proper PowerPoint techniques and Photoshop tricks. Customized small group and one-on-one training is also available by contacting Research Imaging Solutions.
Contact: Beth Beighlie
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