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2007 News Releases from the Office of Public Affairs

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Health Coverage Improves Health and Reduces Major Heart Complications
December 25, 2007 - A 12-year study of over 7,000 Americans shows that individuals without health insurance experience a dramatic improvement in their subsequent health trends when they become eligible for Medicare at age 65.

Kofi Annan and Alice Waters to Receive Global Environmental Citizen Award
December 10, 2007 - The Center for Health and the Global Environment at Harvard Medical School announces that Kofi Annan and Alice Waters will be their 2008 Global Environmental Citizen Award recipients. The Center presents the award each year to individuals that have demonstrated outstanding achievement in furthering our understanding or raising awareness about the importance of the global environment.

Neurons in the Frontal Lobe May Be Responsible for Rational Decision-making
December 10, 2007 - Scientists have found that when monkeys choose between different options, the value neurons assign to each option does not depend on the menu of choices.

Homeless Cells Find Temporary Lodging--and Their Demise
November 29, 2007 - When human cells wander in suspension, free of their normal attachments, many of them launch invasions into their neighbors. These "homeless" cells bore into other cells and hang out inside, where they either die or exit, apparently unscathed. This bizarre phenomenon, which the researchers term entosis, appears to underlie a natural process involving tumor cells inhabiting other tumor cells that pathologists have observed for decades.

Blood Stem Cells Fight Invaders, Study Finds
November 29, 2007 - Researchers have discovered that blood stem cells are capable of patrolling the body’s organs where they seek out, and respond to, pathogens. They appear to be proactive participants in our innate immune response.

Jeffrey Modell Immunology Center Opens
November 17, 2007 - Harvard Medical School officially opened The Jeffrey Modell Immunology Center on Nov. 17. The new Center was made possible by the Jeffrey Modell Foundation (JMF), a non-profit organization established by Vicki and Fred Modell in memory of their son, Jeffrey, who died at the age of 15 from a Primary Immunodeficiency.

Katrina Victims Increasingly Depressed, Traumatized, and Suicidal as Relief Efforts Drag On
October 31, 2007 - According to the most comprehensive survey of people affected by Hurricane Katrina, results of which are being presented today to the U.S. Senate Committee on Homeland Security and Government Affairs Ad Hoc Subcommittee on Disaster Recovery, the percentage of pre-hurricane residents of the affected areas in Alabama, Louisiana, and Mississippi who have mental disorders has increased significantly compared to the situation five to eight months after the hurricane. These findings counter a more typical pattern from previous disasters where prevalence of mental disorders decreases as time passes.

HMOs Fail to Bridge the Gap Between Medicaid and Commercial Patients
October 9, 2007 - Medicaid patients in HMOs fare worse than commercial patients in HMOs. This is the case for both HMOs serving only the Medicaid population and HMOs serving both the Medicaid and the commercial populations.

Researchers Develop Targeted Approach to Pain Management
October 3, 2007 - Scientists have combined a normally inactive lidocaine derivative with capsaicin, the ‘heat’-generating ingredient in chili peppers, to produce pain-specific local anesthesia. When injected into rats, this combination completely blocked pain without interfering with either motor function or sensitivity to non-painful stimuli.

The Harvard Center for Neurodegeneration and Repair Gets a New Name
October 2, 2007 - The Harvard Center for Neurodegeneration and Repair (HCNR) has a new name and tagline: Harvard NeuroDiscovery Center—collaborating to cure neurodegenerative disease. The goal of the name change is to help foster connections with people and organizations that share the Center’s vision to convert promising discoveries into effective treatments and cures for neurodegenerative disease.

Mental Disorders Cause 1.3 Billion Annual Days of Lost Role Perfromancce
October 1, 2007 - A general population survey found that in U.S. adults mental disorders result in more than 1.3 billion days each year out of role—unable to work or carry out usual activities. This number equals roughly half as many days out of role as those associated with all chronic physical conditions combined. Condition-specific estimates show that major depression, in particular, is among the most impairing of all conditions in terms of total lost days of role performance.

Researchers Find Connection Between Caloric Restriction and Longevity
September 20, 2007 - Scientists at Harvard Medical School, Cornell Medical School, and the National Institutes of Health have discovered how caloric restriction enables cells—and many higher mammals—to live longer and healthier lives.

Scientists Synthesize Memory in Yeast Cells
September 14, 2007 - Researchers in the Harvard Medical School Department of Systems Biology have constructed a memory loop out of bits of DNA. After being placed in a yeast cell, the loop continued throughout many cell divisions.

Uninsured Community Health Center Patients Often Have Difficulty Accessing Specialty Services
September 11, 2007 - Uninsured patients who receive their primary health care in publicly funded community health centers face significant obstacles accessing specialty services outside of these centers, even after a physician has deemed them necessary.

Underinsured Children Receive Fewer Vaccines, Study Finds
August 7, 2007 - Due to limited federal and state funding for vaccines, underinsured children in the United States are increasingly at risk for not getting needed vaccines, according to a new study published August 8 in the Journal of the American Medical Association.

Researchers Uncover Risk Genes for Multiple Sclerosis
July 29, 2007 - A study examining the genetic basis of Multiple Sclerosis has confirmed that altered genes in the immune system elevate the risk of developing the neurodegenerative disease.

Obesity Spreads Through Social Networks
July 25, 2007 - A study of 12,067 people over a period of 32 years has found that social networks have a marked influence on weight gain. For example, if a person’s close friend becomes obese, that person’s chances of becoming obese increase 57 percent; for siblings, increase is 40 percent; and for spouses, increase is 37 percent.

Jeffrey S. Flier Named Next Dean of Harvard's Faculty of Medicine
July 11, 2007 - Jeffrey S. Flier, the George C. Reisman Professor of Medicine at Harvard Medical School, will become the new Dean of Harvard’s Faculty of Medicine on September 1, President Drew Faust announced today.

Study Finds Uninsured Adults Increase Medicare Costs
July 9, 2007- While the overall cost-effectiveness of Medicare benefits have been much-debated, new data now show that people who were uninsured before receiving benefits at age 65 required more intensive and costlier care than those who had been privately insured prior to receiving Medicare. These findings, from researchers at Harvard Medical School (HMS), appear in the July 12, issue of the New England Journal of Medicine.

Master Regulatory Gene of Epithelial Stem Cells Identified
May 3, 2007- The skin’s ability to replace the tissue it sloughs off is controlled by a variety of genes. However, a new study from Harvard Medical School published in the May 4 issue of Cell, identifies a “master regulator” of this regeneration process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital tract. This master regulator of epithelial stem cells turns out to be the p63 gene, a close relative to the well-known tumor-suppressing p53 gene. Without p63, mutant mice run out of the regenerative epithelial stem cells. The findings also have implications for cancers of the skin, breast and prostate, which are among the most common human malignancies.

Genome-wide Search Unearths Surprising Clues for Diabetes and Triglycerides
April 26, 2007--Scientists from the Broad Institute of Harvard and MIT, Lund University, and Novartis today announced the discovery of three unsuspected regions of human DNA that contain clear genetic risk factors for type 2 diabetes, and another that is associated with elevated blood triglycerides.

Harvard Medical School and The Culinary Institute of America Launch Healthy Kitchens, Healthy Lives
April 20, 2007 - Harvard Medical School (HMS) and The Culinary Institute of America (CIA) today launched their pioneering initiative Healthy Kitchens, Healthy Lives: A Leadership Conference Bridging Nutrition Science, Health Care, and the Culinary Arts. At this unique, semi-annual gathering—held at the CIA’s Greystone campus in Napa Valley—health professionals from around the country will participate in seminars led by Harvard scientists and in hands-on cooking workshops led by CIA chef-instructors as they explore the delicious possibilities of healthful food and its preparation.

Cholera Makes Protein Analogous to Formin/Spire Hybrid-like Actin
April 19, 2007- Researchers at Harvard Medical School have demonstrated that a type III secretion system (T3SS) is both functional and required for intestinal colonization of Vibrio cholerae in the infant mouse model. Although T3SS have been associated with pathogenic mechanisms in a wide variety of bacteria, until now T3SS have not been described for V. cholerae. The current study, led by John Mekalanos, PhD, chair of the Department of Microbiology and Molecular Genetics, was based on his earlier research which identified a strain of V. cholerae that does not contain virulence factors but does contain components of T3SS. The new findings, which appear in the April 19 issue of Cell Host & Microbe, show that T3SS provide an alternate colonization mechanism that makes a protein analogous to formin/spire hybrid-like actin and causes changes in the cytoskeleton.

Protein Fragments Sequenced in 68 million-year-old Tyrannosaurus Rex
April 11, 2007- In a venture once thought to lie outside the reach of science, researchers from Harvard Medical School and Beth Israel Deaconess Medical Center have captured and sequenced tiny pieces of collagen protein from a 68 million-year-old Tyrannosaurus rex. The protein fragments-seven in all-appear to most closely match amino acid sequences found in collagen of present day chickens, lending support to a recent and still controversial proposal that birds and dinosaurs are evolutionarily related. The HMS and BIDMC researchers, working with scientists at North Carolina State University, report their findings in the April 13 Science.

Weight Gain in Pregnancy Linked to Overweight in Kids
April 2, 2007- Pregnant women who gain excessive or even appropriate weight, according to current guidelines, are four times more likely than women who gain inadequate weight to have a baby who becomes overweight in early childhood. These findings are from a new study at the Department of Ambulatory Care and Prevention of Harvard Medical School and Harvard Pilgrim Health Care and are published in the April issue of the American Journal of Obstetrics and Gynecology.

Significant Prostate Cancer Risk Factors Identified
April 1, 2007- A study led by researchers at the Keck School of Medicine of the University of Southern California and Harvard Medical School has identified seven genetic risk factors-DNA sequences carried by some people but not others-that predict risk for prostate cancer. According to the study's findings, these risk factors are clustered in a single region of the human genome on chromosome 8 and powerfully predict a man's probability of developing prostate cancer. The paper will be published in the online edition of Nature Genetics on April 1.

Discovery Could Lead to New Broad-spectrum Antibiotics
March 23, 2007 Antibiotic resistance has become a major problem not only in hospital settings, but also in the community as well. New antibiotics are needed to overcome these increasingly resistant bacterial infections. Suzanne Walker, PhD, professor of microbiology and molecular genetics at Harvard Medical School, has identified the biosynthetic genes for moenomycin, the only known natural product that directly inhibits an important family of cell wall biosynthetic enzymes. The discovery could lead to new broad-spectrum antibiotics.

High-Deductible Health Plans Linked to Fewer Emergency Room Visits
March 14, 2007 Patients who switched to high-deductible health plans went to the emergency department 10 percent less than patients who remained in traditional plans, according to a new study by the Department of Ambulatory Care and Prevention (of Harvard Medical School and Harvard Pilgrim Health Care). The study, published in the March 14 Journal of the American Medical Association, shows that most of this reduction was for less severe conditions like colds, nausea, and headaches. The authors followed members for approximately one year after the switch to the high-deductible plan.

HMS Center for Health and the Global Environment Honors His Royal Highness The Prince of Wales
January 28, 2007 "We are delighted to honor Prince Charles, whose life's work has so effectively carried out the Center's mission by helping people understand that their health depends on the health of the environment and motivating them to do everything in their power to protect it," says Eric Chivian, MD, director of the Center and co-recipient of the 1985 Nobel Peace Prize.

New Study Suggests Hip Fractures Not Caused by Benzodiazepine
January 16, 2007 Benzodiazepine use was not shown to be associated with hip fractures after all, according to a new study from the Department of Ambulatory Care and Prevention (of Harvard Medical School and Harvard Pilgrim Health Care). Previous epidemiological studies suggesting an association have been used to support legislation and policy decisions that limit access to these drugs among the elderly. These policies may need to be reexamined based on these new findings.

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