- Introduction to Clinical Research Training
- Medical Education
- United Kingdom Clinical Scholars Research Training
- Vanderbilt Hall
- Financial Aid
- Office of the Registrar
- Campus Planning and Facilities
- Ombuds Office
- Committee on Microbiological Safety
- Human Resources
- HMS Foundation Funds
- Office for Academic and Clinical Affairs
- Joint Committee on the Status of Women
- The Academy
- Global Health Research Core
- Global Clinical Scholars Research Training Program
- HMA Standing Committee on Animals
- Office of Research Compliance
- Global & Community Health
- Harvard Medical School Event Calendar
- Contact @HMS
- Office of Diversity RIA Program
- Q&A Archive
- The Dean's Perspective
- Department of Pathology
- HMS NEXT
- Harvard Mahoney Neuroscience Institute
- OHRA Home
- Office of Research Subject Protection
- Tools and Technology
- Alumni Association
- HMS Information Technology
- HMS TransMed Program
- Introduction to the Practice of Medicine
- Office of Communications & External Relations
- Office of Global Education
- test page
- Safety Quality and Informatics Leadership
- Human Resources
- Jobs @ HMS
- Contact us
- Dental Medicine
- Harvard University
New ‘Undiagnosed Disease’ Center Funded by NIH
July 1, 2014
Rare and hard-to-diagnose diseases present extremely difficult problems not only for patients and their families, but also for their physicians who struggle to identify and treat these disorders. Often, patients have persistent symptoms without a diagnosis for years, which can result in treatment delays, repeated diagnostic tests, and increased health care spending.
Now, a new clinical program in Boston, comprised of a consortium of Brigham and Women’s Hospital (BWH), Massachusetts General Hospital (MGH), and Boston Children’s Hospital (BCH) is set to offer new hope to patients who suffer from diseases and symptoms that have eluded diagnosis. Today, the NIH announced a $7.19 million, 4-year grant to fund an interdisciplinary Harvard Center for Integrated Approaches to Undiagnosed Diseases.
The Center will seek to ascertain and characterize undiagnosed diseases in adults and children through a combination of careful clinical evaluation, genetic and genomic analysis, environmental exposure analysis, proteomics, metabolic studies, systems biology, and network medicine analysis. In its first year, the three Boston institutions will enroll and care for 12 patients, increasing to 50 per year by the fourth year.
“Here in Boston we have enormous potential to help these patients by uniting the leading experts from these world-class institutions to bring the latest in medical knowledge and technologies to bear on these difficult cases,” said Joseph Loscalzo, HMS Hersey Professor of the Theory and Practice of Physic, chairman of the Department of Medicine at BWH and principle investigator of the new Center.
The center is one of six new clinical sites that will join and build upon the existing NIH Undiagnosed Diseases Program (UDP) to form the new NIH Undiagnosed Diseases Network (UDN). As announced last January, Harvard Medical School's Center for Biomedical Informatics, under the leadership of center director Isaac Kohane, will coordinate the national network. The UDP has received approximately 10,000 inquiries since 2008, and investigators have evaluated more than 3,000 medical records and admitted 750 patients to the NIH Clinical Center for thorough, one-week evaluations. Through this newly established Network, these resources will be more accessible to patients throughout the country, and more inquiries will be addressed.
“These new UDN clinical sites will enhance coordination and collaboration amongst laboratory and clinical researchers across multiple sites and expand the national knowledge base by sharing resulting data and approaches widely throughout the scientific community,” said Anastasia Wise, program director for the UDN clinical sites.
Evaluating these challenging patients will provide a great opportunity to further integrate the three Boston institutions, bringing to bear a multitude of clinical experts and those at the cutting edge of genomic and other technologies, to solve these puzzling medical cases and in the process contribute to the understanding of mechanisms of disease. A major goal of this program will also be to help train clinicians in the use of contemporary technologies and genomic approaches for medical diagnosis. “One thing that’s very important to us is keeping the patient at the center of what we do,” says Christopher Walsh, HMS Bullard Professor of Pediatrics and Neurology and chief of the Division of Genetics and Genomics at BCH. “All patients enrolled in the Center will have access to specialty care and genetic counseling as we work to solve their diagnostic ‘mystery.’ This isn’t just research, it’s also clinical care.”
Often, patients with undiagnosed disease present compelling research questions. Clarifying the factors that underlie these disorders has the potential to improve understanding of disease processes and of related disorders and their potential treatments. Advances in the science of genetics and genomics in medicine have made it possible to understand the causes and potential targets for treatment of some of these diseases.
“It is likely that many of these undiagnosed diseases are a result of a combination of multiple genetic, environmental, and developmental factors. Genetic sequencing can be a powerful approach to understanding the genetic contributions to undiagnosed diseases; however, these methods alone are unlikely to elucidate the basis for many, if not most, undiagnosed diseases,” said David A. Sweetser, HMS assistant professor of pediatrics and chief of pediatric genetics at MGH.
“This center gives us the opportunity to highlight the utility of modern genomics to human disease,” said Loscalzo. “We are hopeful that the new center will not only provide diagnostic answers and potential therapeutic strategies for those directly seeking a diagnosis, but also that the knowledge gained through the evaluation of these cases will inform our understanding of the many complex diseases we face.”