Research

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Highlights of Notable Research

Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice
McNay DE, Briançon N, Kokoeva MV, Maratos-Flier E, Flier JS
Journal of Clinical Investigation, 122(1), 142-52, January 3, 2012
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Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice
Czupryn A, Zhou YD, Chen X, McNay D, Anderson MP, Flier JS, Macklin JD
Science, 334(6059), 1133-7, November 25, 2011
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Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
Fisher FM, Chui PC, Antonellis PJ, Bina HA, Kharitonenkov A, Flier JS, Maratos-Flier E
Diabetes, 59(11), 4931-40, November 2010
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Lasker Lauds Leptin
Maratos-Flier E, Flier JS
Cell, 143(1), 99-12, October 1, 2010.
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Gut Check: Testing a Role for the Intestinal Microbiome in Human Obesity
Flier JS, Mekalanos JJ
Science Translational Medicine. November 11, 2009.
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Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis
Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E
Endocrinology, 150(11), 4931-40, October 9, 2009
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Evidence for constitutive neural cell proliferation in the adult murine hypothalamus
Kokoeva MV, Yin H, Flier JS
Journal of Comparitive Neurology, 505(2), 209-20, November 10, 2007
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Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARalpha and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States
Badman MK, Pissios P, Kennedy, AR, Koukos G, Flier JS, Maratos-Flier E
Cell Metabolism, 5(6), 426-437, June 6, 2007
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Toll Like Receptor 4 links Innate Immunity And Fatty Acid-Induced Insulin Resistance
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS
Journal of Clinical Investigation, 116(11), 3015-25, November 2006
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Leptin regulation of the mesoaccumbens dopamine pathway
Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS
Neuron, 51(6), 811-22, September 21, 2006
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